Today's episode is sponsored by Apollo Neuro. Apollo Neuro is the leading doctor-recommended wearable technology. Apollo's award-winning SmartVibes AI works effortlessly behind the scenes, automatically integrating into your life to deliver gentle, personalized vibrations that activate your vagus nerve, helping you fall asleep faster, stay asleep longer, and wake up balanced, focused, and ready each day. Not only that, but the Apollo Neuro is the first and only wearable that improves your HRV. Apollo is effortless. Simply wear it throughout the day and night and let it do the work for you. It's safe for anyone and everyone with no side effects and is the only wearable that can be worn anywhere on your body. Optimal health requires both the mind and body to be and Apollo is the key to establishing that connection. Check the description below to save $90 with my special discount. Take control over your health today with Apollo Neuro. All right everybody, welcome back to the Dylan Gemelli Podcast. So I have a special edition special treat for everybody today. I have not done this before. Super blessed to be able to do this. Now, one of my guests is the very first person that's been on here 3 times.
My other guest is making her second appearance. She's had one of my top downloaded episodes. These 2 women are on another level of brilliant, 2 of my favorite people to talk to, to laugh with, to learn from, and who I hold in extremely high regard. One, founder of Terrain Health, COVID expert, such a kindhearted woman, has a new book coming out this year, hopefully. I cannot wait for, that I'm going to encourage everybody to take a look at. My second guest, I have spoken about at length about the impact she's had on me personally, professionally, and every other which way. Founder of Boulder Longevity and well-known all over the place for multitudes of expertise levels. There's not enough that I could say about you both other than I love you both and thank you for coming to see me. It is an honor, blessing, and privilege to introduce to you Dr. Elizabeth Yurth and Dr. Robin Rose.
Dylan, you know, we feel the same about you, so we're honored to be here and thank you for inviting us. Absolutely.
That was a really lovely introduction. Thank you. And the feeling is very mutual.
Thank you so much. Before I get into everything, like I said, there's not enough that I can say. Both of these two, the impact that they've had on me and so many people out there, it— there's not enough that I could say other than please please go educate yourself with both of them. I'll get into how to follow them and everything towards the end, but the wide variety of knowledge base that you guys both have and the hearts in which you deliver this, the motives and everything in between, it has literally changed my life in multitudes of ways. So thanks for coming to see me, and we're gonna get into a lot of stuff today.
Bring it.
All right, Robin and I don't agree on everything, so that'll be perfect.
That's— yeah, that's good.
A lot, but not everything.
No human should ever agree on everything, but a lot we do.
Yeah, a lot we do.
Anybody that says they agree with everybody and everything is bullshit.
But that's true, it is good because that's what provokes thought and like, why you want to go with that? And we're like, you know what, you're right, you're right.
And you know, I always say that's one of the problems, right, is that, you know, you never put dissenting opinions together in, in like medical conferences and things like that. And, and we always say, boy, we'd love to hear these two people who have completely opposite opinions talk against each other. It never happens. No, unfortunately we have mostly the same opinions.
But, but that's good.
Betsy's been like an unbelievable mentor to me in so many ways too, which I'm blessed. I'm blessed to have her in my life and to call her one of my like best friends, the closest friends.
I love that.
I just adore her and she's amazing. Well, she's like an angel helper in my life.
You couldn't agree more. I, I totally agree. Here's one of the things that I like that I want to do with you both is because you may agree on certain things, but you also probably both have more things to add to each other's thoughts and opinions too. And then if you do have a total, a different type of opinion, it'll be good to compare and contrast. We talked about this a lot, um, Elizabeth and I did, in terms of the SGLT2 inhibitors and there's, you know how this goes in our space, especially most people have their own, like Jay Campbell's crazy thoughts that he'll say sometimes that I know irk you even though he's brilliant, but he says some off-the-wall stuff. And I love you, Jay, if you're listening, you know that. But I also know how you are because I've seen your reactions. But that seems to be one of the things we all agree upon is how good these are, what they do, and what the future is holding for them. I know I have to take Jardians, for example, for a specific purpose. But some people just take it just because of the health benefits, longevity.
Yeah.
So what I would like to do is first explain what exactly it is, how it works, its method of function, and then the different reasons why one would take it, whether it's health related or whether it's just because these are what are called sodium glucose transport co-transport inhibitors.
So what they are doing is In the renal tubules, we have these SGLT, these sodium glucose cotransporters that actually reabsorb glucose. So basically you eat something that has glucose, your body's going to reabsorb that into your system to act as a fuel. If you block those cotransporters, instead of that glucose being reabsorbed back into your system, you just pee it out. So basically, inherently, we are actually just lowering the glucose impact that people have when they eat food. Right. And there is huge benefits to that. When we look at, at most of the things we're looking at in longevity, starting with the GLPs, most things that work on metabolic control, be it intermittent fasting, right, or calorie restriction, the biggest pieces that we've seen really have an effect on longevity are things that really make metabolic control pristine. And this is one sort of almost cheater's way in my mind of doing that, right?
Yeah, so I, you know, I've learned a lot from listening to Betsy and also our other colleague, Avid. Dr. Hussain. Yeah, it was Dr. Hussain. So I started really using them. I was using them, I remember the first time I heard Dr. Hussain talk about it at the PwC, like 2, like a year and a half ago, and I was already dabbling in it. And then I really started using them a lot after I heard, all the benefits, 'cause I was using them actually in a lot of my long COVID patients that had significant microclotting. And I found that when I added the SGLT2 inhibitors, they worked really in a very good way in helping sort of like reduce that burden because of all the mechanisms that we can get into or not get into. But anyway, they worked really great for that, and especially also because a lot of them had a lot of insulin glucose dysregulation. So I was having really, and then like my world was blown up when I was like, oh my God, it impacts cardiovascular inflammation, neuroinflammation. It's a gut microbiome modulator. It's a, it's a uricosemic. So a lot of people, and we can get into that being that U-shaped curve with the uric acid and having too much, too little.
And so I found like people that had like a lot of like metabolic, you know, disorders and also that had high, high uric acid, it was a really nice thing to sort of kill two birds with one stone. So, it really has an amazing place for so many things. But again, in the longevity space, it's great because of all of these things. It's like a pleiotropic drug that like impacts all these different pathways, and you can have like massive impact on health.
To me, it's literally one of the most multifaceted drugs that I've ever really come across that does so much, such a variety of things, right? For me, uh, as you know, and some, most do, I had low ejection fraction, and that's why I got put on it. And so I started taking it in June and I was retested in November and I had a 44. Yeah. On the left ejection fraction and it was up to 50 with just Jardiance D-ribose powder and hydroxy ubiquinol in, I don't know, 4 months right around there. So I have to retest again in February hoping it's closer to 55 where it's supposed to be. So what conditions would one use it for? I mean, I'm using it for, I hate to say heart failure, but I guess pre-heart failure or whatever to improve that. But what is it? What's its intended purpose, Jardiance? And then what would, what else could you use it for?
Well, it gotta start as a, just like the GLP-1s, it gotta start as a drug for diabetes.
Mm-hmm.
Right? Because absorbing less glucose, less impact on insulin. So basically we were, had a great drug for helping treat diabetics. When we started to look at its mechanisms, basically by increasing this, you know, metabolic control, you can start to see all of its other benefits. Because if I, you know, you'll get that cardiac function. If the heart really likes to run on fats and ketones and things like that. So if I block glucose, then the heart gets its best fuel.
Mm-hmm.
Right now, almost all of our systems— why I love ketones, right? Or why fasting's so good for us is that we, if we stop the mitochondria from having to work so hard utilizing glucose, we block reactive oxygen species and we use now a better source of fuel.
Right.
So basically by, you know, blocking the glucose, now we're gonna turn to other sources of fuel. When you do that, you're gonna improve immune function, which is why it's so helpful in the long COVID patients, right? We've improved their immune function. We're gonna improve cardiac function cuz the heart works better on that.
Yeah.
And we're gonna improve neural function because we all know, you know, as we know, the dementias and cognitive declines are related to glucose dysregulation in the brain. So we, we've established now a drug that is working on all these factors. And when you reduce the risk of disease from all of these different things, whether it be immune or brain or cardiovascular, you've reduced the risk of death from any source.
What are some other SGLT2 drugs aside from Jardiance that one would be aware of or possibly use?
It's not, yeah, so I usually use empagliflozin, but the other, so canagliflozin is, you know, and so, so there's, there's what are called SGLT1 inhibitors and SGLT2 inhibitors. We don't really want to get into that too much, but the SGLTs are probably the most powerful piece. The SGLT1s may have their place in certain roles, right? So I think that when we look at from our perspective of longevity, we're going to err to the SGLT inhibitors primarily, which is primarily Jardiance or empagliflozin, as opposed to canagliflozin, which has a little bit of SGLT1.
And there may be that, which is the one that has like more, that's more cardiac specific.
Canagliflozin has a little bit more, right? Cardiac specificity.
Yeah. Which might be better for you, but, um, just whatever's going to help.
I think the downside is you also see a little bit more side effects from those drugs and other issues. And that's why I think we've sort of turned in our longevity world to Jardiance. Right. Incredible for kidney function.
Yeah. Oh yeah.
Not have—
yes.
And we don't have— if you look, kidney function declines in almost all of us as we age. Yeah. Right?
Yeah.
And we don't really have any way of treating that. Like when I see somebody whose glomerular filtration rate is dropping, what do we have to offer that patient? Very—
It's a good question.
And, and, and that's— and post-COVID, it seemed that there's so much kidney injury, so much chronic acidosis. Yeah. And so getting them on the empagliflozin or the Jardiance is like really, really important.
I'll tell you why I love it, because it— I mean, I'm in the bathroom peeing a lot, but I told Queenie, I, you know, I, I can eat way more because you're peeing out like 500 calories, right?
Right. And your urine—
so not really considered weight loss drugs, and yet they do honestly, you know, help people with weight loss. Um, I wasn't looking for that, but they definitely help with weight loss.
Oh yeah. Well, I, I was always about 185, and once I started taking it, I eat the same amount I always did and work out the same, and it's— I'm on that 175, 176. 76 range. And it's just, I haven't really changed anything. I eat a little bit more. But you know what, a couple things I've noticed is it, it's triggered heart palpitations for me because of low potassium. Because I sweat so much, I was already running on low potassium and I'm peeing out electrolytes constantly. And what I found, because I couldn't figure out what was happening, and I, I, every time I got potassium test is low, low, low, and I started They put me on a supplement and I started slamming more and slamming more, and then it stops. So it has to be what it is. Um, and then the Entresto was added, and I already have low blood pressure, so I got rid of it because you have to be careful with those things. Yeah, lowering the blood pressure too much.
The other cool thing about the SGLT2 inhibitors are that they're gut microbiome modulators also, which is really neat, right? So like, you're— which is what we're always worried about is like the health of the gut microbiome and you know, maintaining, you know, or restoring health and balance to that microbiome. So I, I love that property of it as well.
I think that's like, could you explain a little bit more about, you mentioned it in the microclotting world, why it's so helpful there?
Yeah. Um, I try to do like a little bit of a deep dive into why it helps with, um, the microclotting. It, I think it, it, I think it, from what I remember, cuz I looked this up like a really long time ago, but I think it does something with, when she was talking about immune function and it has something to do with the endothelial cells. Endothelial cells, right? Yeah, and the endothelial cells, yeah. Because when you have that chronic low-grade endotheliitis, that's obviously activating platelets and then that's also activating the clotting cascade. So when you get to that level, right? Like when you're impacting the endothelial cells there, then you can, you know, get to like, it's like root cause sort of, and you're stopping that sort of like propagation of those or the activation of those, You know, uh, pathways, right?
See, I wasn't aware.
That whole, right?
Yeah.
The whole piece, our immune cells, people don't think about this, but our immune cells are one of the most energy dependent cells in our body.
Right. Mm-hmm.
And we don't really think about that when we're thinking about people who are, you know, poor mitochondrial function, low ATP states. We don't, we think about muscle, we think about heart, we think about brain, but we kind of don't think about that our immune systems are, need more energy. It's why when you look at people with long COVID or fighting viruses in general, all of their energy is going to do their immune cells to help keep this virus at bay. And so that's why they start losing energy to other places like their brain and their heart and their muscles. So if we can make energy more available, so remember, if I'm not going through oxidative phosphorylation, if I'm giving fats or ketone bodies, which is what your body is going to turn to as a fuel when it doesn't have glucose, you make much more ATP per molecule of oxygen. So basically now you've markedly improved energy function because I've swapped out this mitochondria having to work really hard to make energy. I've given them a simple source of energy and it's a better, cleaner source of energy. So that's why it's so, so huge really is we've changed our energy source.
Do you think it's gonna be something that's continuously more prevalently prescribed and used in the future as we see more conditions in areas that it treats?
That's a good question. Is in the— in our world, when we study pathways, we're like, oh my God, who wouldn't?
So in our world, yeah.
So in the good world.
But when you look at, you know, the reason the GLPs caught on and now it's like, oh, they're great for longevity too, is because of the weight loss piece. Right, right. And these don't have that dramatic of an impact there. So I think they're going to be a little harder to grab the attention of these physicians. Physicians grabbed onto the GLPs because their patients were demanding it. Patients aren't going to go in demanding Jardiance, right?
If they knew and understood.
Yeah, right. And so I don't know that doctors are— who are vested in research and looking at all these things are going to have the awareness. So I don't think we're going to see them catch on nearly as rapidly as like the GLP-1 agonist.
That makes sense.
And I went and got the Jardiance card online and it cost me $0.
Oh, that's great.
Seriously.
So Because it is an expensive drug if you don't have diabetes. But usually that only works like 3 months.
Yeah, I got a year off.
Did you?
That's kind of—
Yeah, but even if you compound it, it's not— we actually do, it's not very— yeah, so do we. It's not very expensive.
So if you get it compounded, if you don't have diabetes and you get the— and you get Jardiance, it can be $1,000. Yeah, that's true. So we can get it compounded for much less.
That's what we do.
Yeah, that's excellent. So to shift a little bit then, since you brought up GLP-1s a little bit there, let's do another discussion. Should we talk briefly about this, but let's get more into it. Let's talk about, I want to do some numbers here and maybe some what you've seen with people that you have on it or things that you've observed. So when it comes down to the weight loss use of it and when people stop, how big of an issue is it in terms of their hunger increasing drastically? Have they lost so much muscle that they're gaining a lot of fat back? Like, what do we see in percentage-wise on stoppage and results of weight gain back, and then problems with their eating patterns and everything from, from then on?
Okay, so I am a big proponent of GLP-1s, and I don't really stop my patients.
Okay.
I switch them. So if they were using it, let's say, because they're diabetic and because they have to lose weight, they'll be on more of a standard dosing regimen, right? And then once they've reached their goals and they've gotten to where they are, I then put them to a very low dose or micro, or what they call microdosing.
Yeah.
Because I believe the impact of this, of this drug class is, is so impressive for longevity. And again, you know, we'll get into what the SGLT2 inhibitors do, right? It's the same thing with these, like, pleiotropic, like drug impacts all these different systems, neuro, cardiac, you know, pain modulation, addiction, like all these things that we're gonna get, that we'll talk about, Debbie, Betsy will go into even more depth, I'm sure.
Please.
But I honestly, like, I think they're wonderful. And the problem is, is they get such a bad rap in the mainstream media because they've been megadosed and overused and doctors, and medi spas and all these places are using them and not utilizing the right way, and the patients aren't being counseled the right way. So when you're, you know, when we're using them, right, our patients know that they have to be eating at least 1 pound or more per gram, you know, per gram of protein per body weight, right? That they have to be doing resistance training and exercising and doing all the things to help like, you know, build and maintain lean muscle mass.
Yeah.
Right? They're in a program with us they're doing all the things to maximize the benefits of the GLP-1s. Okay. And so when you have this famous actor or actress that goes on the GLP-1 and all of a sudden you see befores and afters of them on Instagram and TikTok and all that stuff, that's because, yeah, they were being mega-dosed. They weren't being counseled, right, on like how to eat, what to do. They're still going to the best steakhouse every night. They're still drinking every night. They're still, you know, living their stressful life, right? Like we're also like talking about you know, stress management and, you know, helping patients with cortisol dysregulation. All that stuff like plays a role. And also improving the health of their gut microbiome. All that plays a role in metabolic health. These patients are not being counseled that way, right? And then what gets me, and what gets me so pissed off, is that then all of a sudden they go off of it and then they're like, oh, look what happened, they gained all the weight back. It's because of the way they're being dosed and overdosed. And again, not going through the lifestyle modifications and the changes that need to be done, you know, and their labs aren't being, you know, monitored.
Like, there's so many things I can talk about, but it's a shame because they are like the most wonderful, wonderful— like, most of my patients with chronic complex diseases, pretty much every long COVID patient is on a GLP-1 because of what they do for, you know, mitochondrial, um, you know, health as well and efficiency and what they do for all these other pathways. I'm sure Betsy will deep dive into, but they are incredible. And it's a shame, you know, how they've been sort of, um, mis— we've been misinformed about it.
Oh yeah, so completely agree. Let's talk about how big a problem this really is because British Medical Journal— so this just got all this play, right? Because British Medical Journal just came out with an article. It was 37 studies reviewed to really look at what is— how many people truly did regain the weight. And it was high. Uh, 70% of people regained weight. Not all of those back to their baseline, but about 50% or a little over 50% gained back to their baseline, back to where they started, right? So we know it is an issue, right? And as Robin said, it's because people are, are using these in the wrong way. But I want to kind of I want to make a point here, please, that when you look at the number of people who gain the weight back, so about, you know, almost 50% didn't gain the weight back. Look at the number of people who have genetic issues with like the FTO gene. So what is the FTO gene? And it's prominent, especially if you're European Caucasian. It's a prominent gene. So about 40% of people have a mutation in this gene. Which makes their— they have normal GLP receptors, but their body does not respond normally with GLP.
So, so if you look at that, I've got a drug now that treats a genetic disorder. To me, stopping a drug in these people, it would be like, okay, if all of a sudden I came up with a drug that cures cystic fibrosis and I just went, you know what, you just need to breathe better, cystic fibrosis patient, right? You know, you're just not breathing well enough. You know, I'm not going to give you this drug because you just, you know, you just need to breathe harder, right? That's like telling my FTO patient who's a double mutation, you know, is a homozygous mutation FTO, you just need to try harder not to eat because they are never going to be satiated. They are not right now. I have a drug that does exactly what their problem lies. It makes them satiated. Should I stop giving that drug ever?
No.
I have a drug that treats why they're fat. I should never stop it, right? So to say these people are all just going back and eating— yeah, because lots of people don't have the, the messages to their brain to stop eating, right? And now I'm giving them something that actually allows that. So I, like Robin, rarely take my patients off of the GOPs.
Just bring them down.
Yeah, like, I bring them down to a dose and they make great dose, right?
Always long term.
But we are in the minority, right? Most doctors are going to say, hey, you need to be off this drug now. And to me, again, I have a drug now that is treating a genetic disorder, a complication, you know, or someone who just doesn't have the willpower. Yeah, you know, people who have a binge eating disorder, right? Just tell my binge eating disorder patients, oh, you know, just stop throwing up, right? You can't.
Yeah.
So now I have a treatment for it. And, and for me, for doctors to say I can't give this to you anymore because you, you already ran a course and you should just be eating better is Ridiculous.
But because piggybacking off of that, it's the, it's the you don't know what you don't know, right? They don't understand like all these unbelievable benefits, right? And what's so comical about the whole thing is that most conventional doctors don't have problem pushing drugs and prescribing for their patients, but yet this one amazing intervention, they're like, nope, you got to get off of it now because they don't understand really why they were giving it to the person to begin with. And if it was just for the weight loss, part. Well, that's sort of sad, right?
Yeah.
And so they don't have a full understanding.
So we're doing a lot of injustice to patients in this world. And, you know, and so those of you who, who have, you know, who have stopped these drugs and gained the weight back, it's, you know, maybe you just are, you know, are somebody who doesn't give a shit and just eats all the time. But most of those people are not, right? The number of my patients who I've worked with now for 20 years, and, you know, I could tell you they they ate perfectly. I can tell you, I diet logs on them. They were exercising, they're doing everything right and not losing weight. These drugs were a godsend.
Yeah. I just hate though, like how they showcase more of like the famous people or they start like that because that's just like a bad example of like what not to do.
Right.
Right. And those patients aren't again being followed likely in the way that they should be. So that's what I hate about it too. Right. Because of what Betsy says, like, yeah, like if you're going to stop it, you will. Gain it back, probably, in a lot of these patients. But again, I don't think those patients were doing the right thing to begin with anyway, or weren't being followed and monitored and probably treated right, right? And then it, it gets sensationalized, and then it gets a bad rap.
That's it.
I do want to— you know, we really have to get rid of the myth that GLPs cause muscle loss. Yeah, absolutely not. There's zero mechanism that GLP-1 agonists cause muscle loss, right? Not eating, not drinking causes muscle loss, right? You need to drink water. So the drug ones ones, keep going, you get muscle loss. It is, it is very hard. I mean, any of you who have been on them, it's very hard to eat enough when you're on these.
Yeah.
Which is why you have to find the dose that people don't stop eating.
Right. Dose to symptom onset. That's what I do.
When I find my patient can't eat anymore, I'm like, we got to back up. I have to get these calories in you. I have to have you drinking water. So I think that's, you know, retutide as a triple agonist helps a little bit because because it has glucagon agonist activity, so it preferentially loses fat over muscle. So, so you do get red chewy, it's going to be a little bit more protective even if you're not eating enough calories, but not completely. You will still lose muscle on red chewy as well.
Yeah. And that's part of the problem there too, is people don't understand just how hard it is without something like that.
It's so hard to eat enough protein.
Yeah.
My God, so hard to put on even 2 pounds of muscle.
It's really hard. It's hard. Really hard, right?
Yeah, it is hard. And people have this conception in their head that, oh, if I do this or that, if I eat too much, I'm going to gain muscle. It is a terribly difficult thing to do.
It's hard to eat. I mean, you know, I strive to get 120 grams of protein a day. It is a struggle for me as a single.
Well, some— if you're busy like we are, sometimes I put the crack in it.
I get right— it's 2 o'clock, you haven't eaten anything all day. Right now, what are you doing?
The worst patient.
Yeah, it's not my own worst. It's very hard. And so now when you have something suppressing your appetite even harder.
Yes.
You— and just a reminder how important hydration is to muscle, right? If you are underhydrated, you will lose muscle, always, you know. And, and most of us are underhydrated, especially if you're under real—
like, I didn't realize, and that's another thing, just how much I don't drink enough, right? You don't drink enough water during— not even close, especially on like something like Jardiance where you're peeing all the time on top of, right, sweating too, and Yeah, yeah.
And because people also, like, like us who are so busy, it's like, I don't want to drink as much water because then I have to get up and run to the bathroom every minute. And I have patients, right? And I, I have all this work to do. I don't have time to keep running to the bathroom, right?
I'm already in there every 20 minutes.
That is one of the things with SGLTs is they definitely— they need to urinate more, right? Yes, you definitely urinate more. So you're losing some hydration. So you have to encourage people, they've got to be, they've got to be hydrated.
Yeah.
Um, and I love using things like like a plug for IsolWater. You know, IsolWater is an osmotic load of hydration. So you add this to your water.
Yeah.
And it osmotically pushes the hydration into the cells.
It's like intracellular. So, wow. So love, like, you know, and then that, and then that also helps with like protein synthesis, the mitochondria.
So you can get a little bit—
you know what I notice every, I don't know, 3 or 4 weeks, I have this like 2-day period where I weigh like 3 pounds more because I'm holding water because I think I'm not drinking enough and all the peeing. Yeah, it's just like doing that. And then the next day I wake up for like— today it was 3 or 4 pounds lighter because I— yeah, because I went to the bathroom 35 times yesterday.
Yeah.
So sometimes, yeah, if your osmotic load isn't right, it all starts basing, right? It's like, yeah, just got off a plane. Oh yeah. You always subcutaneous fluid that sort of just collected and, you know, it's not doing you any good. You know what the water in the cell—
yeah, that's why I like we use that a lot, the ice. I think it's such a good cheat. It's such a good cheat. Like, they really get—
it's called ice bath.
It's just better.
Osmotic load. So when you drink your water, it goes intracellular instead of extracellular. That's where you want the water. Any of you guys who do like in-body or Siku scans, it gives you like, what is the intracellular water, what is the extracellular water. We really have to get intracellular water.
You got to show me that off camera.
It's awesome. You can easily get it.
Yeah. What if I told you that one molecule helped keep your body's systems cleansed, supported immune health, and cellular protection all at once? I'm talking about glutathione, aka the body's master antioxidant. It exists inside nearly every cell, helping to protect DNA, proteins, and cell membranes from oxidative stress, as well as playing a major role in liver cleansing, mitochondrial energy production, and immune balance. Unfortunately, pollutions, toxins, toxins and stress can rapidly deplete glutathione levels. And as we age, glutathione production decreases as well. And many traditional glutathione supplements do not absorb well, making it extremely difficult to raise intracellular levels where glutathione actually works. And that's why I use Glutaril, the multi-patented topical glutathione developed by the amazing Dr. Nayan Patel. Instead of relying on digestion, Glutaril absorbs through the skin, helping provide a convenient and consistent way to support the body's most important antioxidant system. So use my link in the description and code DYLAN to save 15% off today. So you know what some of this reminds me of is the way the GLP-1s are given out like candy and misunderstood, misdiagnosed, or the, the protocols are all over the place. So it's like when Longevity Clinics came out and testosterone was just wild, wild west, and that's how it started.
Right now it's gone into this to where They're putting people on TRT with 600 and 700 testosterone numbers, people that don't need it, or telling them to run everything under the sun, or the steroid dealer telling them to do this or that. And then people think more is always better. And now it's the same thing with this. And then it draws a bad rap because of course, if you use a gram of testosterone, you're going to have problems.
Exactly.
You know, and then you don't see the good side of it and how it's supposed to be used. And it's terrible.
That's a huge problem in our world, right? And you've seen it with peptides now.
Yeah, why they question— everyone questions everything, right?
And things used inappropriately are going to have bad consequences, and it's not the thing that was the inappropriate use of the thing, right?
Exactly. How prevalent do you think the inappropriate uses of GLP-1s in your eyes? I mean, do you think it's like 50%, 60%? I know it's— there's no way to know, but, and just from what you guys observe, I would say over 50%.
Yeah, it's so hot. Well, how many— just in mind what you guys do to coach everybody getting nutrition, because most, like, even my friends people in my life that I know, they just go to the medispa, go to the— or their doctor, they're like, can you just put me on it? And they just put them on it and it was inappropriate. It's so inappropriate.
It's way very fast to me.
And I'm like, why? I'm like, wait, what? You're— I'm sorry, I'm like, wait, what? You're on like 15 milligrams? I was like, why? Why? Of trazepatide? I was like, what? What?
You know, I mean, how much do you need of that?
Well, it depends on the person. I mean, some people maybe need 15 milligrams, but a lot of people need—
but yeah, start low and go like, see where you sleep. There is that—
the person that works for the where they're still eating enough, right, where they're still getting nutrition, where they're still getting their hydration, right, and they're slowly losing.
And that's a happy patient, actually. That's a much happier patient when it's coming off slowly and slowly, because you're not getting any of the side effects and you're only getting the benefits, and you feel so good. And it's okay for it to happen slowly. You don't have to lose 20 pounds in like 2 weeks.
It's important to remember that where, where our toxins are held too, right, in our fat. So rapidly lose weight, you gave yourself a humongous toxin.
Totally right.
Why then you'll see people get sick and, you know, and have—
that's why they feel complications.
Well, too much too fast is very, very, very problematic, whether it's the guy's steroids going crazy high or this crazy diet and going crazy low. The amount of stress and strain on ligaments, tendons, joints, and then cellularly and everything else.
And again, it's the majority, not the minority.
And when you lose that much weight that fast, it's not good up here either.
Oh my God, terrible.
And there was that toxin, toxin release when you look at it.
Yeah, yeah.
But neurologically, how, how negative is that? I mean, can't that just throw you off all the way around? Thinking all over the place, inability to focus. I mean, that's kind of what I wanted to talk to you too about, because we— I, I've never had this discussion with either one of you, and what I really learned the past probably 6 months is because I've always been so into fitness and nutrition and now cellular stuff and everything else. I haven't done one thing neuroscience, neurological, nothing. And I realized what I've been missing. And, and, but you know what it kind of took was looking at myself and going, man, why are you such a dick? Like constantly? And why are you having an inability to focus? And why are you so stressed? And why do you sleep so bad? And then I started to piece this stuff together and go, man, it's because you're not working on anything up here. You're so worried about this that you're not really that healthy because of your stress, because of all this.
It is one of the top 3 things that is dealt with in any of my patients. Like, we— the neuro piece is huge for—
but I would say most doctors, yeah, ignore it, right? People don't come to us— it's nice, brain fog and things like that, but most people are coming to use for, you know, ED or weight loss or fatigue. Those are the number one people. So, you know, when you look at longevity clinics, how much work are they doing looking at cognitive function? I think it's very—
it's still—
we're not doing measurements, right? We're not getting baseline measurements. So people are following baseline measurements, and we do in my clinic, but most clinics don't, you know. And so I think it's even in our longevity world, it's a little bit neglected.
I agree.
Now obviously if you get the rest of the body healthy, the brain is gonna be healthier, but there's a lot more pieces to that, right? Right. Yeah.
And you want to, and I think like, again, I'm all about averting the crisis and being proactive. So I'm looking at a lot of these biomarkers baseline. And if I see red flags in the workup, the initial workup I'm doing, then I'm gonna do an even deeper dive. Right. Right. And then that way you can really regress. And when you catch the patients early like this, you really can reverse. Reverse or regress what's starting, you know, because the first point of like the first, um, step is really just this like sort of development of neuroinflammation, right, before it becomes vascular, before then it becomes neurodegenerative, like these three steps. So getting them at that point is so important, right?
Yeah. And I want to get into the markers and the things that you look at. You go to the doctor or whatever, they're not really asking you, well, how's your stress? Well, how's your sleep? Then they're looking at basic BS markers that really aren't that important. And if your stress level is so high, it's increasing inflammation, cortisol, who knows what else, and the effects that it has on everything that you're doing, sleep especially. And so like what I've tried to do is really integrate beyond my prayers, which is so important to me, is like that peaceful walk and appreciation of, of the, my surroundings and of nature and the vitamin G of gratitude, which actually is importance.
Yeah, right. Yeah, journaling, gratitude, meditation. We, we talk a lot about how the value of meditation— it's hard to do, it's hard, but now we have cheaper ways of doing meditation, right? There's things like BrainTap, there's tools that we can use to help us.
How big of a priority should this be though? I mean, shouldn't it be number one?
I think that— well, you, you've said this a bunch in a bunch of her awesome posts that she, she's talked— that she posts. But basically, and when you look at the pillars of health, right? And like, you know, movement, you know, movement, nutrition, stress management. Sleep is your foundational pillar. If you don't have that person sleeping, how are they going to heal? When you sleep is when you repair, regenerate. That's when your glymph, the glymphatic system is working during that night to drain all the garbage and the toxin and all the horrible things out of your brain. If you're not sleeping, getting into good deep sleep, and so that's not going to function and work properly. Mm-hmm. Right? So just that. Just by getting your patients to sleep, right? And giving them good advice on sleep hygiene and, you know, really working on that circadian clock is hugely important in reducing neuroinflammation, right? Just that alone, you know, we can get into all the cool stuff, but God, you gotta address that, you know? And that does overlap with, you know, stress management and cortisol dysregulation and getting that cortisol curve to like behave the way it should, like come up and then slowly come down.
And then cortisol passes the baton to melatonin and you can get into sleep. Like, all those things are so important, right?
Yeah. And, you know, add that, you know, when you look at sleep, it still does come down to some of the foundational stuff. When you, you have to have optimized hormones, right? So, you know, again, progesterone— if you're like—
yeah, you need—
both men and women need progesterone to, to sleep, and then need more testosterone to help sleep. So, so we have to not forget that the basics— if somebody comes in your office and you want to work on sleep You still have to start with some of the basic things, right? Do they have the tools necessary? Yeah. You know, to sleep. But yeah, obviously those pillars are so, so hugely critical. And when you look at now all these companies coming out, like I get Instagram all, all day long, I'm sure you guys do, with just, or this is your, you know, $499 lab test.
Right, right.
And so now you got, you have literally every marker.
It's like, what do you do with it?
What do you do with it?
Right.
And you know, and you can run it to ChatGPT and that's great. And Chat does an amazing job, but Chat doesn't counsel you on all these other pieces and how it all fits together. And you have to be careful 'cause chat will go to the very worst scenario on those labs. So I was having some issues, I was having some issues, like, you know, like kind of multiple things. I ran it through Claude. Literally by the end of the conversation, Claude's like, you most certainly have metastatic cancer. You should see somebody.
But that's why people come to us, right?
Oh yeah, 'cause—
Because of the—
Hey, I'm with you.
I've seen some of that and I'm like, I think it'd be interesting. Well, but you have to be able to weed through it, right? Because they have to go to the worst-case scenario, more like liability perspective. So you've got to sort of piece back the person to go— it also will give you 500 things to do.
Yeah.
And, you know, we know people can only do so many things at one time.
Well, and like a lot of side effects can really pinpoint to like 20 different things or 30 different things, so you have to be aware of that too.
Yeah.
I used to do that where I'd look at that and be like, oh my gosh, and I'd be in these panics and then I'm like, dude, just—
yeah, you're making it worse.
You just make it worse.
I always tell my patients, I'm like, really? You graduated from Google Medical School in, in a day? Congratulations.
I do love my patients are trying.
No, it's fine, but they need us. That's why they have us. And how about that?
I'm gonna realize we aren't going to replace a good health coach, physician, right? Whoever it might be to sit down with you and help walk you through things, right? Um, You know, back to the brain health, obviously. Yeah. Those pillars are so foundational, but so is everything else, right? The micronutrients are so, so critical. The hormones are so critical to brain health. And then I, I think that we aren't, we are forgetting the building blocks that, that the brain and neurons in general need, like plasmalogens.
Yeah.
I would tell you 90% of doctors have no idea what a plasmalogens is.
90, even I would say 99%. What do you mean?
Like, you know, we, we in off-world, we have no idea. I would tell you, like, in our longevity docs group, they don't know who is— nobody knows what a plasmalogen is.
Well, what is it? Tell everybody.
So plasma is a very specialized type of phospholipid, and you're, you, you make them from your peroxisomes. You can't eat them, you can't take them in.
Well, technically, but not that— not what's nice, right?
Right. So, so basically, your peroxisomes, your cells make these, and what they are is— think about them as kind of protective layer on all of your neurons, right? Mm-hmm. So, so they are, I like to think about like they're the, the insulation on all the wiring. Mm-hmm.
Okay. All right.
The first thing that happens if you get sick, you get a virus, you get stressed, is you lose those plasmalogens. Now, if your mitochondria aren't perfect, your peroxisomes aren't perfect, you're not gonna replace them. And now what happens? Your body actually starts taking them away from you. So it's trying to now take these and, and you know, and you start demyelinating. So the brain will suffer, your nerves will suffer. Almost everybody as we age gets plasmalogen deficiency, some people more than others.
Okay.
So because we can't just all of a sudden make your body make more peroxides, make, you know, have peroxides that make, you know, we can do things that will help, but we still have to replace the plasmalogens. Almost all of us need plasmalogen replacement. And because you really can't just eat them and get them to your brain, there's only one. So Prodrome Sciences came up with a precursor that can go to the brain and become a plasmalogen. Really?
And they extract it from egg yolk, right? From the yolk? From the yolk?
Well, no, it's because it's—
it's a—
or it's synthesized. No, it's got— so it's not choline. So egg yolk has choline in it, right? So lots of times it's put together with an egg yolk choline. So you can take it with— you can just take plasmalogen itself, which is synthesized. It's a synthesized specialized phosphatidylethanolamine that actually is, you know, has to be, has to be made. So the precursor has to be made that can convert.
So it's synth, it's synthesis otherwise. Yeah. So you get that prodrome sign, prodrome sign, and then that crosses the blood-brain barrier. That, which he's describing, is what gets across the blood-brain barrier.
We'll measure plasmalogen levels on people. And if you do not have enough plasmalogens, I don't care what you do.
It doesn't matter.
You're not gonna repair your brain.
When would those start to decline? Is it different for everybody? And is there a climate world?
Is there lifestyle things that all of us with the exposures that we've had and how many vaccines we've had or how many like exposures to COVID, probably many of us are at a plasmalogen deficit.
So you could be young and that could—
Yeah.
Oh yeah. Oh yeah. I measure all the time young people and I've had young, you know, some of my really young patients and end up with long COVID people. Everybody.
Okay.
Yeah, we— but yeah, I mean, in a perfect world, probably around 50, we all decline.
Yeah. But in our, our COVID world, that are probably much earlier than that.
So the only way to fix this is this?
Yeah.
Is that a product people can buy, or—
yeah, it was actually developed as really as a, as a drug for treating these kids who have a disorder where they can't make plasmalagins. They all died by the time they were 6.
So would you notice this cognitively?
Yeah, well, he's done— like, she— Betsy you know, is in his— what is it, like, your elite practitioners group? Yeah. But like, he— like, I spend a little time with him. He's unbelievably brilliant. And I mean, the scans that he— he's done, what, thousands of scans where he shows like the gray and white matter changes in the brain, like before— even in like a person, like one of our colleagues did this. Did you do it too? Yeah, because I saw one of our, you know, said whatever, our very good friend, we— I saw her scan and it's insane. Like what she looked like prior to plasmalogens and then after.
Right. We used to say you couldn't grow a new brain. You absolutely can't. You can now have a whole series of patients where we've shown they have, you know, 20% loss of gray matter, they have white matter lesions, and now we've fixed them right over time.
So this is totally fixable.
And yeah, it can be. Yeah. Well, and again, this is all now since 2006, a group of—
this is Dr. Goodnow, right? A group of patients with Rush University. Of who have the APOE4 gene.
Okay.
As long as those people's plasmalogens stay high, they did not develop.
Really?
I've said this before and I like it when I lecture and stuff, but like even one mild or asymptomatic case of COVID and even a young 19, 20, 21-year-old, one case, there are brain, like permanent brain changes, like on the MRI. Like this has been, this has been published a bunch of times already in the last like year and a half, 2 years, and that there's decreased cerebral, um, cerebral blood flow to the brain. There's changes on the gray matter, the white matter. And this is from one asymptomatic or mild case. So imagine what's happening. And so if you can get these plasmalogens into you, right, this is going to be, you know, such a saving grace for so many people. And, you know, we're, you know, we talk to people like all over, you know, the country that, you know, specialize in different things like, you know, Amy who does ALS and things like that. I mean, you have no idea what, what we're seeing. Like, she has 19-year-olds with ALS, 21-year-olds with ALS. She has— like, we've never seen neurodegenerative diseases, like, presenting in such young ages.
We're like a completely different world.
We're in a complete— like, dementia, Parkinson's has gone up by 50%, like, from the beginning of the pandemic to 2023, when you look at the trends. And, you know, when you— you can verify this when you talk to the neurologists that are actually looking at this. And, you know, the functional neurologists are people like, like these brilliant people that are running ALS clinics and things like that, like what they're seeing. And again, how it is a true age accelerant because you're seeing such earlier presentations than like we ever have before.
I've had COVID 7 or 8 times, right? So I'm probably really bad there.
Yeah. So you really have to be proactive and you have to— so you can look at markers like P-tau, uh, you know, and, and galectin-3, and you can look at these markers that tell us, yeah, your brain is in trouble. People see those numbers and immediately doctors 'Oh, you have Alzheimer's.' No, you have a neuroinflammation brain, correct, that we can treat.
That you can, and you can, and you'll— and once you get a lot of these things on board that you're doing for neuroenhancement, or, you know, get, you know, bathing that brain with all the things it needs, it goes— you can reverse the markers.
Okay.
Which is really cool. It's really cool.
And all the, yeah, typical doctors do is go, 'Oh, you have this mark. Yeah, you have early Alzheimer's.
Let's start you on these.' But not even that, or they're like, 'Uh, nah,' they don't even do— or they're just like, 'Help me,' or the Waiting for the symptoms to catch up with the biochemical, right? You know, with your, with your biochemistry, right? That's what's so infuriating, right? Because you can stop it in its tracks.
So we kind of need to be looking at these things and, you know, and even, you know, we do, uh, Wavi. Wavi actually, I'm using a machine called NeuroCatch now that actually can show when you start losing some energy to your brain, right?
Okay.
So think about the first, the first thing that happens in neurodegeneration is it's an ATP deficit, which is why That's why ketones and those kinds of things are so helpful is 'cause they're gonna increase energy to the brain. But you can look at a marker called a P300 wave on these EEG tests that show you even really before you see P-tau go up or things like that, you can see the patient, the brain is losing energy, it's losing ATP, it's declining in function. And you know, there's norms for age because we sort of assume everybody's gonna decline and we really shouldn't be assuming that, right?
Yeah.
We should be doing the things to, to be neuroprotective. So we really, I, I, I agree with you. I think the brain gets sadly really neglected in our world. We're a lot more interested in body composition and, you know, and sex drive and everything else. And the last, I, you know, the last thing they really think about really is, is the colon.
It's so easy to just go, oh, I'm stressed so I can't think, or whatever.
And ever, that's the excuse. I'm like so stressed, or oh my God, it's my hormones, or— but no, it's not. It's really— maybe that's a little part.
Yeah, that, that too. I was gonna say it's either, oh, I'm so stressed, or oh, I didn't sleep good.
And, or most women that are like in their late 40s, it's always like, oh no, it doesn't— perimenopause. No.
Yeah, well, because we just look for an excuse to tell ourselves it's fine or whatever, and it's okay.
We need to be looking at these things and people.
Yeah, but you can really save these people. Like, you can really decrease morbidity.
I do not buy into that, oh, it's inevitable, or always you get this age, just gonna have a—
could definitely change the course of that person's, you know, health span for sure.
And the point in, in this whole thing and everything we do is never accept what someone says, that, oh, that's just what's going to happen, because it's That's not true. I mean, there's certain things that are inevitable, but you can certainly mitigate, prevent, or protect, right?
Yeah.
I mean, in all of these, I hate that. And it's kind of like with the plaque in the arteries, you can't reverse it. Bullshit. Yeah, this is bullshit. You certainly can.
You can.
Yeah. And all of these things they say you can't, you can't.
And then it's this acceptance that this is normal, right? Yeah. I don't know how I'm going to get a brain MRI scan that says normal atrophy.
You're like, what?
No, your brain should not shrink, right? There's not normal. Actually, there's not normal for age. There is normal, optimal, and not optimal, right? There's not normal for age. And that's how we look at every marker— testosterone, uh, you know, even blood, even your blood work, blood work, right?
Yeah, the ranges are based off of your age.
Yeah, and I hate that too. Like, testosterone levels are based on what the average, right?
Like, how healthy, right?
Like, I mean, how many people do you get coming to you and they're like like in range and they're in the 200s.
I have young— I have 30-something-year-olds like that, 20-something-year-olds like that.
So let me ask you then, why do you think that, I don't know, the last 5 or 10 years that the averages have just gone down so much? And why at such a young age we're seeing lower levels of testosterone that are just— some of the things I see without steroid— with steroid use, I expect it, but without— I'm seeing some of these and I'm like, what the hell is happening here? What's the problem?
Well, certainly environmental toxins.
Yes, I was going to say endocrine disruptors.
What are some of those? Just examples.
Glyphosate, BPA, plastics, BPA. But beyond that, there's a little bit of this unfortunate demasculinization of men. Right.
Yeah.
That we, you know, it's actually not okay to be masculine anymore.
Right.
It's called toxic masculinity. And actually, we would like boys to be boys. We would like them. Yeah.
Okay.
A little bit more aggressive, a little bit more. That's what they're supposed to be doing. Yeah. When somebody keeps telling you that's not— don't act that way, don't be that way. That's not really what boys were designed for. Well, you don't have to be impolite and rude, but you, you, you should still be a man, right? You should still be— yeah. You know, I want my 18-year-old to have a little bit more aggressiveness than my 18-year-old. And, you know, so I think there's unfortunately now, and when you don't reinforce that with, you know, more sports and more, you know, these sort of interactions and you're just sitting there playing video games.
That's not going to improve testosterone.
That's not going to help with growth hormones.
Growth hormones has value.
You should be outside. You need to be, you know, you need to be a boy. You need to be— So I hate this whole toxic masculinity.
Such a great point. Amazing.
It's sad.
I agree.
Frustrating as hell.
So, you know, it terrifies me for my boys because it's always being shoved down, right? Oh, you know, you can't act like that, you can't do that. You know, boys are supposed to be, you know, in school not being able to sit still. And, you know, I mean, that's just boys, and it's okay, and we should foster that and learn how to teach them the way they should be taught, which is moving and active and doing things. Absolutely. So, you know, we, we really have unfortunately created a society where we want low testosterone. It's better, you're more passive.
And look, and you know how unhealthy that is for you? It's terrible.
It is literally like one of the things I despise the most of the with shit that gets thrown in our faces and what I see and what they try to tell you is how you're supposed to be, which is the polar opposite of how we were designed.
This is an amazing, amazing point that Betsy brings up. I mean, I will also say added to that is like the lives that we live, you know, like the, the constant stress, the constant going.
You think cortisol and stuff like that is a problem? Constant looking at screens and inability to communicate and that dysregulates your cortisol.
Like, what do you mean? And then when you're— and then the lack of sleep too. Like, you produce testosterone in the wee early morning of the, you know, wee early hours of morning. I can't talk. But yeah, like, that's huge, right?
And so, well, it speaks to COVID's effect on—
yeah, please, how was that affected? The level like that?
I'm sure the spike protein has a very high affinity for the testicles and the ovaries and everything. Um, yeah, it's really impacted. I mean, I've never seen so many men, so many young men with such— every— I would say 9.5 out of 10 people come in my office, not with like— even just my regular like patients that aren't seemingly coming in for like long COVID or something, they're testosterone deficient.
Yeah, really?
Like people just coming in to help me me with like gut, you know, gut stuff, GI stuff, whatever, you know, or like some other, you know.
And none of that with the rise in infertility.
Yeah.
On both male and female.
They have noticed nobody makes testosterone.
So many of my young female patients have lost their cycles.
Dysmenorrhea. Yeah. Amenorrhea. Agreed. Agreed.
Or anovulatory cycles, ovulating anymore. You've been crawling. It has been huge. And again, even of course, people who've got a few, you know, you know, didn't get horribly sick, but they got COVID a few times. We are seeing this too. Yeah, really?
So common.
Is there a type of diet that's having a negative effect too on, on testosterone levels?
I mean, like, I mean, just the standard environment. Yeah, terrible for you. All the— what do you see? Yeah, high fructose corn syrup. It's literally in every— like, if you look at a label, that's like one of the first ingredients on anything that's packed.
You're telling me the labels with 20 and 30 ingredients aren't good? Yeah. What you're trying to say, you think it's like eating that Cake Factory menu of my life.
Yeah, protein, protein, protein. And like, oh, but what about like, let's— I love the cholesterol thing too. I feel like it's so important.
Put your cholesterol too low.
Oh my God.
You know, they had my cholesterol down in the 30s, my LDL, and I panicked.
And told him, go back to the brain.
And the doctor's not happy. He's like, look at this.
No, they were. Oh, this is great.
This is where we want you.
And I said, what? No, no.
That's like your rate limiting, like, you know, that's the rate limiting stuff for all of your hormones, like to produce all your hormones and your glucocorticoids and all your stuff. Like, that's insane, right? And then, you know, Betsy can talk more about too, but Dr. Goodenow, he shows that like the low cholesterol correlates with lower brain volume, right?
We're seeing smaller brain volume with people who have— so, so we absolutely know that we don't want to push cholesterol.
It doesn't— don't we need like fats for cellular membranes and the protection and things? Yeah, you know, I, I told you this before, but I lived on that low-fat diet even though I was coaching against it for like 15 years. And I believe that's probably why I had some of the heart problems that I had, because when I flipped like the pyramid now— yeah, so I went from like 25 grams of fat a day to 130 is what I eat now.
Yeah.
And I'm— my HDL went up 40 points. Wow. And my ability to—
that's amazing.
Oh, it did. It went from the 40s to, to the right at 80 in like 2 to 3 months of switching and doing all of these animal fats. And you know how pissed off I for not eating grass-fed butter every day and the things I cook.
Yes.
But having like these whole good foods and prioritizing protein and fats. So I guess my question then for you guys is on the way that the food has flipped now. Mm-hmm. Because some people still have this inability to understand the needs for fats and the things that are prioritized now as we know they should be. For you on a normal diet that you feel is good, do you feel like, uh, that is where we need to be and then carbohydrates would be on the lower end? Or how do you guys structure or find a— and I know it's different if you're bodybuilding or something or training for something, you need a little bit higher carbs, but in general, normal people, how do you prioritize, um, macros for your diets?
Well, I love the new pyramid. We have to remember the first pyramid was designed for the, you know, the companies like Kellogg's.
Yeah.
You know, I mean, that's really where it came from.
Yeah.
It had nothing to do with health. It came with keeping these big companies and big money happy. Right. So we know that this is a much better way to go. You've got to be prioritizing proteins and fats and have carbohydrates on the lower side. Now, there are people who do need more carbohydrates despite even if you're not in the bodybuilder world. And I think one of the things is looking at timing of carbohydrates to appropriately utilize them, you know, correctly. And we, we We still— our body still likes glucose, right? So, so it still is a good fuel source. You know, fats and ketones are a faster, cleaner way of making energy, but glucose is still a useful way of making energy going through oxidative phosphorylation. So I think that we forget that, that, you know, the zero-carb diet, you'll actually— you know, people who are just following a ketogenic diet forever, you will lose metabolic flexibility. Yeah. See a decline in cell health and in mitochondrial function.
Yeah.
The mitochondria are like to be able to switch fuels. The healthiest people can switch between, between a glucose-fed state and a ketone fat-fed state. And if you never do that, you'll actually see over time mitochondrial function decline.
Okay. So that's what I was going to talk about was the metabolic flexibility aspect.
If you're going to do it, if you're going to do, you know, if you, if you say, I feel great on ketone diet. And I have patients who do. You really need to cycle in and out of it.
That's what I thought, and that's where I was kind of going structurally. For me, on the changes, I've gone like 40/40 protein, fats, and 20 carbs. But you know how much I train, so I've kind of been thinking, yeah, I probably need a little bit, a little bit more, right? So I've tried to bump that number up, and I'm just playing and testing with stuff, you know. And I think that people that train a lot need more carbohydrates, and so then that poses the question, which kind of carbs do you think that you would recommend, and what should people stay away from that are causing a lot of the problems?
So, well, I was gonna just say, you know, piggybacking off protein, fat, which are great, like understanding— like you have to have a good understanding of the type of fat, right? And what fat you're taking, that's really important, right? Because people are like, oh, well, this is saturated, this is unsaturated, but what is it? What is the fat? And like patients, like I am still careful with my ApoE E44s and my ApoE34s. And how much fat, how much saturated fat? Yeah, they can have— you have to be careful because you don't want to, like, you don't want to amplify that gene, right? So you have to be careful. So, like, and Betsy does too, like, we check an ApoE in everyone, right? Because if you want to be able to, like, take care of your patients properly, that's like a good gene to look at.
What gene is that for everybody listening?
That ApoE? Yeah, apolipoprotein.
The fat transport protein. Yeah. Uh, so if you're a 2/2 or 2/3 or 3/3, you have a normal risk of dementia. If you're a 3/4, it's increased. If you're a 4/4, it's marked.
20. Yeah. 12% of increased risk of like dementia.
Okay. Of course.
And, and because the, the fat transport for the brain is, is altered.
Mm-hmm.
You need to be a little bit more careful with how those people are eating fat.
I see.
Okay. Yeah. So you wanna be careful with that. It also impacts heart Cardiovascular health too. They're both— it's like people always like focus on dementia, but it's cardiovascular health as well. So you wanna just like, you know, it's really good marker to have. Like, you know, Betsy and I were talking, we're not the biggest like SNPs people, like get 20,000 SNPs and you know, like you're, you know, the, um, gene testing when you do, you know, 'cause not all of them, you're— it's not every one of them that's, you know, that you're necessarily manifesting, right? And you don't know what, you know, based on your epigenetics, what's going on with those. But there are certain mutations like APOE, MTHFR, we talk about that later. Yeah. That you wanna like know. So that you could take better care of your patients and do a lot of preventative medicine about, uh, around. But anyway, so what I'm saying is, is the fats— I love the fats. But, and, and then we said it briefly too, like seed oils. Yeah, that's like really important. Like, people have to like understand like what that is.
That omega-3:6 ratio, yeah, really critical longevity. Yeah, yeah, right.
Yeah.
When you're eating a lot of seed oils, your omega-6s go very high and that ratio gets obscured. It is a very good longevity marker. Yeah, an inflammatory marker.
But, but the thing with the 6s, and this is what I've learned, is that those are adulterated 6s, right?
They're like that, right?
We get really good, right?
But you need—
that's— yeah, so like when you supplement, sometimes you could be doing a little bit more harm to the ratio. Like, that's why like you have to be careful with unadulterated 6s to 3s and making sure that ratio is, is right.
Type of omega-6.
Yeah, yeah.
Actually use arachidonic acid, or, you know, adrenic and arachidonic acid, those are omega-6s. But we get the bad.
We don't want the bad 6s, right?
The good. So that's where those seed oils comes in.
Yeah, you know. Yeah, I mean, that's— they're in— like, if you look at the label, even like, they're like, oh, but I'm eating organic tortilla chips. Yeah, and I'm eating organic. It's like, do you know how— like, you look at that, it's like sunflower oil, safflower oil, palm oil, you know, like, and all these things that say they're organic too. So you have to lay it under— you know, that's right. Yeah, you don't know what you're getting.
Why do you think I never eat out. Yeah, once to twice a year maybe, if Queenie makes me.
But now she doesn't.
But it's like building— it's like getting the patients to build the plate, right? Right. And then, and then building the plate based on what your biomarkers are, right? Because somebody might be more cardiometabolic and also need like low glycemic index, like a more low glycemic impact diet and stuff like that. But like, yeah, I, I'm so such a proponent of having this like higher protein good fats, you know, and like, yeah, like maybe not as much carbs, but like good complex carbs, like no refined sugars, like none of the garbage, but really good complex carbohydrates, you know, to fuel you.
Yeah, so carbs have gotten a little bit too shamed.
I like carbs. Carbs, I mean, I'm a carb girl, I'll tell you right now. I like—
I say, you go, the way you train and have trouble keeping weight on, but you may need a few more carbs, right?
I, I don't like crave carbs or anything like that. Yeah, I get most of mine from like vegetables and fruits. And great, you know, I do the pomegranate juice because I know for the heart.
Oh, the palm. Yeah, yeah, yeah. I love the palm.
Yeah, you do.
Did you do the testing or the pomegranate into your elephant?
You're not separate.
The good superfood.
Yeah, no, I do that juice every day. And yeah, but I don't— and I, you know, I'm Italian. And of course, so I ate pasta all the time as a kid, but I don't, yeah, crave it. But I do try to keep it very structurally sound and what I do take in. And I can't stand these fears of fruits and the things that people say. I'm like, brother, just don't eat pounds of fruit a day, but you do need some, right?
Yeah. You know, and if you have a problem, just again, lower glycemic. Yeah, like low, you know, the ones that have a lower glycemic index. Yeah, yeah, the berries. Yeah, exactly.
So what are some other ones? Like, I, I know everybody's always going to say sweet potatoes, so we know that is going to be one. I tend If I do do it, the purple ones, the—
the amazing. Yeah, amazing.
Make me feel heavy for some reason, but I still have them sometimes because they are so good. But what are some other ones? So we got vegetables, fruits, sweet potatoes. What about like rice or oats or anything like that? What are you guys' thoughts?
White rice can be a very— like, you know, I'm a rice child. And very interestingly, you know, one of the ways you can sort of lower the glycemic impacts of rice is to cook it ahead of time, keep it in the refrigerator and then reheat it.
Same, same with potatoes, with a white potato. Yeah.
Okay.
Or even, even pastas, if you eat them by— cook in the fridge, in the fridge, and then reheat it, you've lowered the glycemic index.
Okay.
Um, so, but I think, you know, white— what people always think, well, the brown rices are better. Actually, white rice is probably a clean—
white rice is better, I think. Yeah. Okay. All right.
I like my basmati. I do like a jasmine basmati combination. It's so delicious.
Such a good— like, you mix that with your meats and some And that's so good.
I love over— like, I love a good, like, gluten-free version of, like, overnight, like, whole, like, overnight oats, like, mixed with, like, chia seeds.
I'm like, I heard soft Dave asked me what that comes out.
I'm sorry, Dave, but I do. I think it's okay to have in moderation.
Like, ate so much oatmeal for so many years, I can't even eat it at all.
Yeah, I wouldn't say instant oatmeal. I say, like, the whole oatmeal.
I mean, the big No, but I'm just— that they absorb a lot of toxins. Yeah, I know, I don't know. It's really the toxins they're absorbed. I swear, you'll be a little careful with oats because they do— they're really, you know, like oat milk's probably one of the most toxic.
We talked about it.
So is that it? Now it really can—
I don't like it.
Oats love to absorb toxins out of the soil.
I did like 15 years of 3 servings a day.
They're good. Have them in moderate— this is my point— like having— it's all like about moderation.
Moderation. Because, you know, we all get on—
because you have to be able to enjoy your life still and be able to have things that make you happy.
It's easy though when you haven't had something for a while and then you eat it and then you want it all the time, right? You know what I mean? I've, I've been that type to where I'm like, oh shit, just, just let's not, just get that word, right?
You need GLP-1 for that.
Yeah, right.
Yeah, if you had a GLP-1, you'd be okay.
I think sometimes too, the older you get, the more control that you seem to have. Or maybe it's just my lack of desire to eat because I get so busy to work or whatever. It's probably I swear to you though, the foods I prioritize now are all things I wouldn't touch like 2 years ago, and that I can't live without them now.
So let's see here.
Avocados.
Oh, I was gonna say avocados are wonderful.
You know, I eat— I went in, so I, I went into the kitchen one day and I told Queenie, because I'm like the spur of the moment guy where just cars will show up, just whatever, I just— shit just comes and I'm just like that. So she's used to it. And I went in there and I know She's prayed for years about me just stopping the— because I've had eating disorders from modeling and being in bodybuilding and just as a kid, and it just never went away.
Yeah.
And I was— you know how I train.
Yeah.
1,500, 1,600 calories a day is always eating for years. I'm burning 4,000.
You're doing this long endurance.
Oh yeah. So I went in one day and I said, okay, I can't, I can't live like this anymore. I'm gonna try all this shit I tell you I don't like salmon, avocados. We're going to Whole Foods, pounds of meat. And then I started going down the line— elk, venison, had them all. And I can't— this is what I eat every day: avocado, whole eggs, not just egg whites, full fat yogurt.
Well, that— can we talk— well, can we go back to the egg white versus whole egg?
I love this discussion.
Oh my God, the egg—
oh, you finished, and then we'll go back to that because it's really important. And I have this argument with like my— even my friends or my patients like all the time.
So I was eating 10 to 12 just egg Bites.
Never, because bodybuilders, you're just mass and protein. Yeah, all right, no calories.
Full-fat yogurt instead of low-fat, and just the disgusting nature of the low-fat, not to mention all they strip out of it every day.
So you were eating the low-fat yogurt?
Yeah, the fat-free, plain, terrible— oh yeah, the, the most dreadful thing in the world. And, and then I have to mix all kinds of shit in there to make it even palatable, right? Um, and then all of these grass-fed meats and beefs every day, fatty fish. But then I do like to mix in this sea bass for you, you and everything. But these are the things, like, I'll sit down and have damn near 1,000-calorie meal because the avocado, I'll do— I used to do 80 grams, then I did 100, then it was 150, then it was 200, you know. And so it's a good range. And then the Ezekiel bread, I wouldn't touch bread. The good cheeses, the pecorinos and those things, all these things I have now, I wouldn't touch any of them. Wouldn't touch all the things I listed, none of it. Now it's all you'd ever say.
But when you come from your world of, you know, you know, I work with a lot of bodybuilders, you know, when you come from that world of the such disrupted protein. It's, you know, you know, where you're trying to massively just eat tons of protein but no calories, and, you know, and terrible nutrient loss that occurs with that.
And, you know, you know, I don't eat chicken. I don't even touch it.
I don't even like it because you're so sick of it.
I'm so sick of it. And then I realized this sucks. Like, it does. Aside from chicken thighs, I think it all just— it's so dry and bland. Yeah, they're good.
That's what I'm saying.
That's the only one I even touch.
Yeah.
They're freaking great. But I wouldn't even look at them, right? You know, because I was terrified I was the exception. Yeah, that bullshit that doesn't exist.
Yeah.
So it just opened up a whole new world for me. And I say that to humanize myself, but to tell others, like, if you're living in that fear or whatever— I'm the leanest I've been aside from steroid use.
No, you look great. You feel great.
Yeah, I do. I mean, aside from the matter irritation sometimes with all the work and everything. Yeah, I feel phenomenal and I'm not miserable, one, hungry all day, right?
Yeah.
You know, eating 13 servings of vegetables a day, which is what I was doing, snacking all day on peppers and onions and that crap. That's— I like, but you don't want to eat that all day, you know? And I think that a lot of people lack— either they're not eating enough because, like, we're talking about, they're busy, they're scared, they want to lose weight and all of that. And I think if people ate more, they'd realize they burn more. Right. Yeah. But that's what I want to talk to you guys about because we talked about this. I like to measure my breath in the morning to see how my flexibility is and what I'm burning and everything. If you're a constant—
what are you measuring it with?
The Lumen.
Oh, you're using the Lumen? I used to use that a lot. Yeah, I practice.
Yeah, I love it.
You like it?
I do, just because I like to know, like, okay, sleep effects, if you wake up, right, about fat burning and everything. But I like to see— I'll take what I did, if I mix something up the day before, test it and see, did I eat too late? Did I do this? Did I have a little extra of this? And compare it. And some days it's just off. But you talked about in class we had that if you wake up really hungry in the morning or whatever, you're kind of in the carb burning stage. Can you— can we talk about what it means when you wake up if you're like sugar carb burning as opposed to fat burning? How we want to be, what that all means, and how we stay metabolically flexible?
Because I think people don't Yeah, I mean, really, you know, when you wake up absolutely starving, right, when you wake up in the morning, you are just like, oh my God, I have to get to food. Likely you produced a lot of cortisol, you know, overnight. You, um, you spiked up glucose and insulin overnight, and then you crashed it, right? So you were in this completely, you know, just glycolytically starved state, and your body craves something right away, right? So craves something immediately. To try and get some glucose back. You just had this big spike of glucose, either maybe because you ate a high-carb meal before the night before, lots of times because of stress. So we get these big cortisol spikes at night and we see this all the time, right? And you can do, you can monitor with CGMs and see LCPs.
Yes, we do that.
In the middle of the night, right? And you know, and then what happens? You know, cortisol spikes, glucose spikes, insulin spikes. Now what happens? Blood sugar drops out. You wake up. I'm like, I'm ravenous. I need my, I need glucose, right? Yeah. Whereas we can keep ourselves in a more more, you know, ketonic state a little bit. So by eating something like a protein before you go to bed, so that basically you blunt that effect. So even if I have, if I have a little bit of protein on board, even if I have this cortisol glucose insulin spike, it's going to be blunted somewhat by having this little. So sometimes I'll have people do a little bit of protein so they just don't wake up completely the same day, right? You do a small protein load before they go to bed and to keep them more stable through the night.
Yeah.
You know, and now CGMs, you know, I think the Lumen is great. We can do so much now with CGMs too to help people figure this out. Yeah. What is happening to them? How are they keeping their glucose nice and stable?
Yeah, I do. So I take the yogurt, mix protein powder in it, and then a little bit of fruit. And that's like, I have a couple bites before bed and I don't need a tablespoon of almond butter.
Don't need a lot. Stabilizes.
Yeah, we do like a tablespoon of like a nut butter or like maybe if they have like a little bit of a whey protein, a whey protein, like a whey-based protein powder, like with a little bit.
And those are the people too, you got to say, you know, we need to work on Cortisol. Why are you cortisol?
Cortisol, right. The cortisol, right. Like, I mean, it's really amazing 'cause we do CGMs. I've been doing them for years in my practice and it's really unbelievable the amount of patients you see with these really high glucose levels, like throughout, especially women. It's insane. It's actually really crazy. And then, yeah, of course. And then because of that driving the cortisol and glucose are married, right? So like you're, and then you're becoming, you're breeding more insulin resistance. And I love the CGM because it's really, this is really unbelievable to me too, and fascinating to me rather, that like you can have like 2 people, right? With like even maybe similar glucose spikes and like in, you know, readings on the CGM, but their biochemical individuality is so different that like when you pair them with certain foods, like one person, like Betsy might have to be paired differently than I have to be paired so that you avoid those. That's why I love like the CGM 'cause of that amazing biofeedback. Stuff like that.
Like my partner doctor was saying, he was doing a CGM, he sent me, he ate half a banana, half a banana. Spikes are going crazy.
But not for someone else.
I can eat banana and I'm fine, right? So it is really interesting how different things like that. Oh, my spikes were somebody and not somebody else's. Really individualized.
And that's where precision medicine comes in because again, like everyone wants everything to be boilerplate and wants it to be like, oh, a protocol. Oh, well, if this person is having all these spikes and having issues in the more, like what we were just talking about, what you intervene with and what you give them could be totally different different for, you know, patient A versus B, right? And so you have to have that understanding and knowledge of like, yeah, I need a watcher who has a neuropathy and is—
him going to see is a little bit high and he has like a cookie every day. I go, you're gonna have to stop the cookie. I'm not gonna stop my cookies. So I put up CGM.
Cookie didn't do it.
It was like, did nothing to him, but he would have these horrible cortisol spikes at night.
Why do we not want glucose spikes or too high at once?
Because that's going to bleed in, that's going to bleed into your—
I know the answer. You're looking at me like, what's wrong with you? I want them to know. I know the answer.
Okay. Sorry, I wasn't trying to be—
You're looking at me like, what happened to you, Dylan?
High glucose spike, high insulin.
Right, right, right. And then insulin—
glucose is not the evil thing.
It's insulin. And then eventually the receptors get desensitized to insulin and you have more nervous— right.
So what's gonna— is, is it just foods that cause this, or stress, or combinations?
Yeah, like stress is huge. I mean, and even like going back to stress, like cortisol dysregulation is probably the biggest— I think one of the biggest drivers of like why we have insulin resistance. And then, and that's also messing up your sleep and whatever. And like, and then that messes up your gut microbiome, because when you have high cortisol and you feel stressed, you want comfort food. And then you're going back to like refined sugars and bad garbage food, and then your gut microbiome is getting screwed up and you're becoming more constipated. Like there's like, and then your vagus nerve is like becoming super floppy. And like, there's just like so many things like happening.
Alcohol, will that cause it too?
Alcohol's terrible.
That's what I—
alcohol's just a pure glucose load, right? At least when you're eating a cookie, you got a little bit of fiber, you've got maybe, you know, other things that— something.
And it's a direct, it's a direct toxicant to your mitochondria. Mitochondria girl. See, the alcohol direct toxicant is terrible.
I honestly have this argument with my children who are all, you you know, teens and 20s about, you know, drinking. Because it didn't— like, by 20, I was like, you, you know, I can't socially interact without drinking. And I'm like, you can't. You really can't.
I used to think this.
Or do you have fun? Drink and make sure you're like— and when you're drinking, like, not on an empty stomach, and not like— it's like, it's how you do it. And also, I feel like certain alcohols are— I know it sounds ridiculous— are a little better for you, are cleaner for you.
Like, that, that we need to just get. And I don't know how you hit the young people. I think our generations are now getting a little bit more like, alcohol's just bad, I don't need it. How do you hit the young people? How do you hit the frat bros who still, you know, party every weekend and get drunk off the bus? I don't know how to change that behavior.
It's hard.
It's really hard. It's hard. They are too invincible to tell you, you know, every time you're doing that, even though you're 18, it is really messing your brain up. I don't know how we impact that population.
It's tough.
And your liver, it's very— and then your gut.
All we're trying to do is give the information that doesn't scare people. Like, when I deliver it, I'm like, listen, I've done all this shit. This is what it is. Do whatever you want because I'm not going to lose sleep. But look, this is what it does, and this is what it's going to end up when you're older. Sometimes it's just how you say it, because if you bring it across in a fearful way or a lecturing type of way, they just don't listen. They just shut off. That's not going to happen to me. That's not going to happen to me. I start telling stories about shit that's happened to me, and the way I convey—
stories are great, right? People actually hear real life. It's like your story has gone a long way to change people, right? You know, so I think stories are a really good tool to do that. Yeah, but it— to me, it's one of my number one— our medicine needs to be started earlier, right? We need to get people in their 20s interested in looking at this stuff. You know, looking at their markers, understanding that you might my 26-year-old son has horrible lipids. It's just his, his genetics, right? If I can address those now and really get him optimized there, you know, his Lp(a) as high as ApoB—
that's where I was going.
Yeah, we can save him a whole lot of trouble. We're seeing people now, we're trying to backtrack. If we can start getting out to the younger generation, and, you know, I hope just when I see people, you know, our age have kids, that they— the kids start picking it up, right?
You know, we gotta teach like parents and things that they need to look at in their kids, because like you said, Lp(a), had I known that Right. Or maybe I never—
they don't even check an insulin level. Yeah. On like patients that you're like, an insulin level's not even checked.
That's insane.
And I tell like a lot of them, I'm like, make sure they check an insulin level. I'm like, tell them to do advanced cardiac, like advanced cardio, like in a cardio IQ or like get them LabCorp. Yeah. I'm like, look at these other inflammatory biomarkers. Like that's the thing. That's a big fallacy, right? Like everyone thinks the LDL is the biggest deal. I'm like, look at, it's all these other inflammatory biomarkers that like are driven—
stress, right? Alcoholic does not become a problem until oxidizing. So if you don't say any stress, even Lp(a) is not a problem until you have oxidative stress. Yeah, Lp(a), remember, has some protective properties. It exists for a reason, right? Otherwise all you Lp(a) people would have died off, right?
Right.
It's there because it actually has some protective role against viruses and things like that. There is some protective role to it. It in itself is not a horrible thing. It's oxidative stress along with an Lp(a). So if you have a perfect, you know, redox and no— it doesn't matter, your Lp(a) is not going to kill it, right?
But everyone thinks it's going to help them, and they're still going to get, you know, plasmapheresis, or like try to, you know, they're trying to do all these things to lower it, but they could be working on the other thing. So that, right, like, like myeloperoxidase is a great oxidative stress marker, biomarker.
Ferritin, right?
Yeah, yeah, yeah, true.
And doctors don't know that, right?
Yeah. And, and, and, and fer— and not ferritin, and MPO. Like, I am not kidding you, I have never seen seen so many elevated MPOs, like post-COVID especially. And it was funny, one of our— my colleagues—
that creates such an oxidant.
Yeah. And that's a good marker to like follow, as like you see that coming down, you're like, wow, this— you're, you're in a better place, right? And like, I have one of— like a good friend of ours, actually, a, you know, dear colleague of mine who, you know, does the advanced, you know, um, lipid panel, like the Cardio IQ or They do the MPO all the time. And he's like, yeah, I stopped checking the MPO. I'm like, why? He's like, it's elevated in everybody. I'm like, what do you mean?
I'm like, no.
And I'm like, no, no, no. I was like, that's okay. I was like, you're going to use that as a marker, as a marker to show that like things are improving, right? And that you're addressing the oxidative stress and that you're right. It's like, but yeah, that's what, that's what's happening. Like people just don't want to deal with it. They're like, why is everyone's high now? I'm like, this is wrong. I'm like, no, it's actually not a great marker that nobody— it's like, no, it's not.
You know, I think that that cardiac IQ is one of the most important panels to—
agree. And not even the cardiologists look at LP little— looking at some of these, like, an average myself every 6 months sometimes, right?
Just so I can— because I'm really dialed into mine. So, and then for people listening, particle sizes, ApoB little a, all of these things that they don't look at are the shit that's really important.
Correct.
I mean, the other stuff is like secondary in my view. Um, total HDL, LDL. I want to ask one more thing before we shift on the glucose spike stuff. So what have what if, so let's say we've got a meal on the plate and one of the things I've learned to control that if you have carbs on the plate is to eat the protein first, then the fat, then the carbs, and that's exactly control the spike. You guys agree?
'Cause that is gonna, that's impacting your gastric emptying too.
Yeah.
Yeah. Like how fast you're emptying and you're getting full.
Is some of you guys have heard me talk about trehalose, which is a, oh yeah, it's trehalose.
Yeah.
Trehalose is a, a 2 glucose molecules hooked together.
Mm-hmm.
And it has zero glycemic impact. It's also really good for your brain. So it actually Actually, they're using it now as a drug to treat MS. So trehalose is a really interesting sugar in that it actually completely blunts, not completely, but pretty significantly blocks glycemic impact of foods. So if you're going to eat something that's a high-carb meal, eat your protein first. But one of the things you can do is just drink like a little lemon water with trehalose, which tastes like lemonade. Drink that. You're going to see, you know, and this is where CGMs are fun, right? You can see almost no impact on your blood glucose. So I love using trehalose.
How much trehalose do you have then? Like, add.
I have them do like 5 grams.
5 grams.
Yeah. It's like that.
Good little hack.
So I love that.
She's— I've heard her tell me this.
It's amazing. Plus it has so many neural benefits. So it's such amazing sugar to use. It has zero calories, zero glycemic impact. It has a few calories, but zero glycemic impact. And it's neuroprotective. And it blunts the cortisol response and the insulin response. This is an amazing sugar.
Everyone should just have that before dinner. Use it like a glass of it before dinner. And it's yummy, right?
You drink lemon water with trehalose, it's like drink a little yamain before your dinner. It's huge.
I love it.
So I add that to my protein shake in the morning. You know, I do 5 grams at least 3 times a day. So it's huge.
So morning time, what do you, what do you recommend for people like high protein mornings, fat mornings? What's a good thing for people to take in? Because that's, that's one of the most confusing. Like what should they be eating? Yeah, like because some people say don't eat breakfast at all. Some people want you to eat eat this fucking tremendous 12 from Perkins or whatever. Like, what, what, what do you guys recommend for morning consumption?
Well, I think you need to have at least a 12 to 16 hour fast, right? You know, I think—
I agree.
So if you— I felt like you ate—
except for very ill patients, I don't fast them because I feel like their, their body—
I used to do longer fasts, and that's where CGM helped me a lot. I'll show you my very worst days. When you Something like you and I who are thin, don't know, you know, all of us who are thin and don't have a lot of extra, when we fast, it's a little bit of a stress to our body, right?
It harms me.
So my glucose, you should see how it spikes on my fasting days. So, you know, so I think that, you know, if you're eating dinner, you know, the best thing is to eat dinner earlier, but that's just so hard with most of our life.
So many studies that show that too. Like I heard this, yeah, there's, I watched this whole woman speak on dinner while it's still light out.
Not really, you know, but it's hard.
I don't get home from work for the sun, or like as the sun's going down or something, you know.
So, so if you ate dinner at 8 o'clock, you know, you wouldn't want to have something to eat until at least 10 o'clock. Yeah, 10 or noon, right? So yeah, I do think that, that it, it's not so much important as, you know, do you eat breakfast, do you not? If you ate dinner at 5 o'clock, then probably it's a great thing.
It's the timing. It's not so much, right? It's a timing thing, correctly, whatever you want to call it.
Yeah.
Eggs.
Meal number 1.
I said eggs.
I, I was saying that's what you, that's by far the best, the very best eggs. I, of all my patients try to eat 3 eggs a day.
That's great for your brain.
I, and that's where the whole egg white, right? Egg whites are all the choline, all the good stuff is in the yolk, is in the yolks. Egg yolks are the most valuable nutrient.
I have 4 a day.
Yeah.
Guaranteed 4 a day.
But everyone's like, but my cholesterol's gonna go up.
Oh shit.
And they have no effect on cholesterol.
And have, people that say that have no understanding or grasp of what kind of cholesterol is coming from an egg. Right.
And, and what it actually does.
Eggs are so good.
When you look at my favorite food in the world, choline is— almost all of us are deficient in choline. And so you need so much choline, and eggs are by far one of the richest sources.
I think if you forced me to say, Dylan, you have to pick one food you have every day, you only get one, it would probably be eggs. Yeah, yeah.
I think, I think that's—
it's always going to be good.
I might want pizza.
I might do this. When I was still smoking pot, I would have said pizza too, for sure. Right?
Favorite food ever. Ever. Yeah, like I have patients do eggs with some avocado. Oh yeah, like it's like the best.
I started to put avocado because I just have it on toast and eggs and everything, and a couple days I didn't have time and I was like, I gotta get more nutrients. And so I started putting it in like the meats that I was cooking and stuff.
And oh my gosh, with the egg?
No, just so cook— like I'll cook like 3/4 pound of elk, for instance, and then I I would put 100 grams of avocado in it after I cooked it, mixed it in. Yeah, sometimes I'll drape an egg over it too.
A couple. Yeah, I want—
and shit, it's so good. Okay, I got, I want to, I want to talk about your staples, like supplement.
Oh.
And I want you to gimme 5 staples. And I, and, and I understand like magnesium, vitamin D. I'm talking—
oh, you don't wanna talk about magnesium?
No, let's not talk about, I'm talking like a creatine or something else, a different type of supplement that you say is good. And then gimme a couple that are just like unnecessary, like, you know where I'm going. Going with like BCAAs or something like off the beaten—
you're saying more off the beaten track? Yeah, people aren't like thinking about that they're putting in, that we— they should infuse into their day.
Yeah, yeah.
Because I think we know certain vitamins and minerals that we absolutely have to need. I want to get more out there a little bit with you.
All right, you want to go?
Yeah, if we're not going to talk about all the basic things that you have, so you need your B vitamins, you need different minerals, we've covered that so many times. My, you know, like kind of off the beaten path.
Yeah.
One is gonna be ketones, because I can reduce inflammation with ketones. I can give myself brain energy, muscle energy. I can, I can, I mean, ketones will honestly, you could, you could live on ketones. I mean, so it, it, it goes so far in all these certain pathways, right? It rests my mitochondria. Everything I'm gonna talk about is gonna be focused on, I'm gonna try and keep my mitochondria as healthy as possible. Okay, so it's going to be then probably alpha-ketoglutarate. Urolithin A is going to be high. So those are really, you know, if you start looking at Urolithin A, especially higher dose effect on mitochondria, so huge. Alpha-ketoglutarate, underutilized, very underutilized in terms of mitochondrial function, essential for mitochondrial health. You know, I will put cycling high-dose bromidine because high-dose bromidine also has so— and we're talking about getting up into like a 20-milligram same dose, um, and cycling that is so beneficial for mitophagy. I think what I— so if I put together those 4 things, I'm gonna keep my mitochondria pretty humming, honestly.
Ultra stack. Yeah, I take a heavy dose of urolithin A. Yeah, I do.
That's because you get it for free. That's the rest of us have to pay.
Yeah, why do you get it for free? You know who they are. That's your sponsor.
Yeah, I do like 1,250 50 milligrams.
I think an optimal dose, honestly, I know they're coming out, anything that's more in the gram range, but I actually think like when my people are sick, I'll go up to 1,500 milligrams.
Oh shit. Yeah, I, I, they need at least probably a gram a day. Yeah, honestly, I think so. Yeah, I think so. They, they do 500, but they say a gram would be the rule, right? You know, but it'll kill you.
You need to know, we've been talking about you in our group too, like using a gram at least for like the last two, like last year and a half or two.
Yeah, I take a, I take a capsule of a full stick powder thing and then a gummy every day, so it's $12.50.
I think one of the biggest problems in a little bit in our world— and we do this with peptides and we do it with something— is underdosing things. Yeah, right. Oh, you're not dosed because of cost and, you know, and see, you profile— like, you don't want to put on a label, but then it goes, well, are these— because now someone's gonna take 8, right?
Yeah.
So, so the, the biggest issue, like, our initial recommendation is 6 milligrams. If you go back and look at the studies that was nothing. Yeah, now we know we probably need closer to 20 milligrams. I think Urolithin A is like that. I don't know that 500 milligrams is probably enough if you're super healthy and everything's fine. If you have any order or things like that, you probably need a gram. Alpha-ketoglutarate, you need at least 3 grams. The dosing is 500 milligrams. I mean, you know, so I think we're— we're, you know, when you look at packaging, you look at what liability-wise labeling has to do, we are underutilizing a lot of really good.
Oh, I agree. I see it all the time. A lot of products that have like 6, 7 ingredients, right?
Yeah, those are probably the worst, right? Oh, this looks great, it's got all this cool stuff in it, but look at the numbers. All microdosed.
Yeah, because that's the only way to actually sell it and not have to be, you know, the SLOUP 332 dose used to be like tiny microgram that people recommended, and I see all these studies about 50 milligrams. I mean, what for?
What?
I'm not a fan.
For what?
Okay, yeah, I'm You know, uh, we can have a whole discussion on SLEPP, why it's bad for us. I have to do that one later.
What's your top?
So I love this, um, product called OG, ozonated glycerin. Tell me, because I just think it just, you know, can kill so many birds with one stone. But it's basically, um, like, you know how you have hydrogen peroxide? It's a glucose peroxide. So instead of like throwing like, you know, basically like giving, you know, giving it to someone and like causes a fire. This is like sort of like lighting a candle.
Okay.
And like it basically, the ozone is like diffusing and getting to where it has to go. It lights the filament, whatever. And if Fetsy's saying that, come on. Now, and it basically, you know, really pushes right across the cell membrane, gets into the mitochondria, like does its job.
Okay.
Right? Because of the way it's designed. 'cause of this glucose, you know, 'cause it's a glucose peroxide. But what's really cool about it is when you ingest it, and the Japanese have done like dozens and dozens of studies, they actually were studying ozonated glycerin for diabetes as like a cure for diabetes because it really helps fasting glucose levels.
Okay.
Which you wouldn't think 'cause it's a glucose peroxide. It's like sort of counterintuitive, but because of how it behaves intracellularly and what it does, it causes like this specific type of gradient radiant that causes glucose to be taken up, and it— and basically you can utilize glucose more efficiently. But anyway, you can heal a lot of stuff with it.
Yeah.
So, so really what's cool about it is, is when you ingest it orally, it gets absorbed in the very first part of your duodenum, in the first part of your, um, of your small intestine. And so systemically, it has a lot of impacts because it obviously can get everywhere across the membrane barrier. So it can really help with a lot of things from like different pulmonary diseases, like people with bronchiectasis, like refractory TB. It's been used in like different neurodegenerative disease states and you can nebulize it, you can inhale it, you can take it orally, all these different things. So.
And it's around so long.
It's been around so the, right. So the backstory is so interesting. So when it was presented at the conference that I went to like a year ago, Basically this very, you know, brilliant physician scientist back in the late 1800s. He studied it immensely and he was curing everything, like all these basically, you know, diseases back then that you didn't have antibiotics for, you didn't have penicillin, like you couldn't cure any of these things. And he was like getting people better, all these different viral diseases, bacterial, you know, infectious diseases and things like that. And he would wrote like 15 different, um, additions to like his work, right? And I guess he passed away in the beginning of the 1900s, and in— it's literally all of these editions and like all of his works that he wrote, like all these things that he wrote about, they've been sitting in plain sight at the Library of Congress. So a bunch of these guys, then the— like a bunch of these physicians that are like super cool and like cowboys and like, like to learn all this stuff in the ozone space, they got these works and started like, like, and started reading reading all of his, you know, books, and they were able to figure out like, oh my God, this is how we're going to dose this, this is what we're going to do, all the things.
And it's really safe, like you can't really like overdose it, and you can actually give it IV, and you can combine it with DMSO IV, and it's actually fantastic what it can do for like all different things, especially autonomic dysfunction, um, uh, you know, cancer, you know, other complex chronic illnesses. But I love it just something to build immune resilience, right? And something to support your mitochondria. And if you wanna— and also it has, it has activity against viral lipid, lipid-enveloped and non-lipid-enveloped viruses. So, and most bacteria. And so it's really great, you know, antimicrobial. If you wanna get it into your gut to do good stuff in your gut or kill any like bad bacteria or bacteriophages like COVID, you have to like combine it with like a chia seed or something so that you can push it into the gut because it gets absorbed so quickly in the small intestine. But, um, yeah, we use a lot. I use it intranasally every day actually to prevent myself from getting sick. Like, I do one spray in each nostril like twice a day, and then if I feel like maybe something's coming on, I'll use it more.
I mean, you just dilute it down, and then we use it topically with DMSO. So like in a very, in a 4:1 solution or even like a more diluted solution. But the 4:1 solution is great for like anyone with different, you know, dermatitis, like dermatitis, like psoriasis, eczema, wounds. Yeah. Like weird, bizarre rashes, anything that's like hot and erythematous, like it takes away and it's a very, very potent analgesic. And the last thing I'll say about it is it does not disrupt the gut microbiome. Microbiome. That's what I was saying with Japanese. They studied this extensively and they showed that it only kills the good bacteria and not the bad, which I think is super, super fascinating and cool.
Oh, like here's the bad bacteria, not the good?
Yeah, sorry, thanks. That's why I had— that's why she's sitting next to me. It kills the bad, not the good, and it leaves the good away. Like when you study it, like even like at 30 days, 60 days, 90 days, is like you might get a little drop in the good, but all the bad are gone and it really doesn't really mess with the good bacteria.
Fascinating. Well, I'm building a list of stuff that I need to start getting.
And the plantarogens, right?
That's plantarogens. And then maybe I should quickly talk about the Thea Antibiotic 'cause I do like it a lot for gut. So Thea Antibiotic is basically you take healthy donor stool and you autoclave it, you autoclave the crap out of it, no pun intended, and you're left with like 13,000 to 15,000 different bioactive compounds, which are your metabolites that the good bacteria make. So you're getting really healthy donor stool with the right bacteria, the right balance of bacteria that make all these beautiful postbiotics or metabolites, right? And so why I like it so much is because when you use probiotics, right, that's like, you know, yeah, I think a Probiotics, they're good and for some reasons, but I think of them as sort of like tourists, right? They're like passing through your gut, you know, and they're giving you those things like temporarily where this is sort of like you're not depending on the actual bacteria or probiotic, you're just showering that person with all these amazing metabolites. And they've done like, you know, they have studies that, you know, show like, you know, its efficacy and different things that it can help with, but it does seem to really help patients like with autoimmune diseases, with the leaky gut, you know, because it's really helping with that short-chain fatty acid replacement and all the other metabolites that are gonna help seal the gut up and also providing some of those bioactive compounds that the good bacteria in your gut wanna feed off of, right?
So I have a lot of good success in, you know, basically when I'm dealing with patients for gut restoration and repair, like with using that product and it having like a good impact. Act.
One more question then before we finish. What would be one for each of you that you think is often used and is completely unnecessary?
Well, you brought up branched-chain amino acids. You know, honestly, branched-chain amino acids, I know people, and if you're fasting and you want to get some branched-chain amino acids, go ahead. But truly, the branched-chain amino acids need a full spectrum of, from the protein. They need all the amino acids to really do their job and not kick one, you know, sort of overflow one pathway and not another. There's really zero evidence that you're not better off just eating protein than taking your silly branched-chain amino acids.
What about the EAAs?
And I think EAAs can be— the essential amino acids can be, can be useful. Okay, so I, I, I have no qualms against using the essential amino acids in people, and we will see deficiencies in those a lot of times when we look at micronutrient testing, where I do need to replace those in people, especially people who have been sick or older people But all you guys who are taking your BCAAs, just eat some freaking protein, right?
So a post-workout, just drink protein, drink protein, drink protein. Yeah.
Eat the protein. Yeah.
Eat the protein. It's just silly.
Okay.
And again, it can actually create, when you look at what happens metabolomically, you'll see a different metabolomic pattern in somebody who takes BCAAs and somebody who ate protein. And it's not a healthy one.
Really interesting.
Okay.
I don't know.
You don't have blood.
Well, I just had one in my head and it slipped out and I went away.
There's just—
the problem is, is there's a lot of nonsensical marketing too and things that are—
oh, I know. Well, it's silly, sort of.
No, nothing.
But I, I think people are such suckers that just— that don't know better, right? That just take a regular multivitamin. Yeah, because all you're doing is just creating expensive pee. Now let me qualify that. Hold So like most multivitamins out there, right? Just have the little bit, littlest bit of each thing, right? Mm-hmm. The littlest bit of all these different minerals and vitamins. And you need such a high dose of each one of those things. Now granted, in our space and some companies that we work with, they make, or what they call it, a good multivitamin. There is some good multivitamins. There are some good ones that have really good high doses of zinc, selenium, you know, like all the minerals, your vitamin D, A, you know, all those things. Things that makes a difference, right? But I would say when I, when my patients are like, what do you mean I'm not taking my most? Like, I'm like, no, I was like, you don't need that anymore, right? I'm like, you need all these things.
These multi-products that have, you know, they're not getting enough. I could take this one pill, has this and this and this and this, and the dose line is way too small to do anything. But it's a great marketing gimmick.
Yeah, it goes back, right? We had a whole conversation about this this past weekend, right? Like, you have this cool product that has like all these different things, let's say for even mitochondria, right?
But like, it's not enough.
Of like each thing.
And they try to tell you, oh, because of the synergy between them. But there's such little synergy because you're getting a little bit of a lot of things.
And take that into account in somebody that like doesn't have a good like gut microbiome, which most people do, and they're not absorbing properly. Exactly. I mean, it just, it's just diluted and diluted products. Yeah. So anyway, all right, that was— I'm not as, not as, um, not a big— create, not of create, not as creative in thinking of which supplement.
But it's actually, I've been arguing this for such a long time. And if you're buying a $20 multivitamin, you're probably not getting much of anything. You're getting a 5,000% of vitamins.
I said, like, expensive pee. Yeah, expensive urine. No, and, and it's just getting peed out.
Overdoing it on the cheap stuff and then not giving you anything of the important stuff is what they do, right? It's just people don't know anybody. Yeah, they look at price tags and go, well, this one's $25 cheaper than the other. Well, there's a reason.
You know that.
So, oh my gosh, you guys, I could go for another 6 or 7 hours with you because, well, I look at the clock and I'm like, well, how the hell did we go?
We were only gonna talk 90 minutes.
What happened?
Oh wait, that would be— yes, but I—
what did we go for?
Almost 2 hours.
Oh my God, that was so fun though.
Well, I haven't had a fraction of enough, so I, I would ask you guys to come again when we can do this again because This was damn fun.
You and I talked about talking about some cool peptides and things like that.
Well, yeah, we got— well, we got a million topics to go back to. So what's the good—
we do. We have a lot of topics.
What do you guys have coming up new? You both have books coming, right? I mean, what do you guys have coming? Tell me. And so we can tell everybody and share you with the world, please.
So I'm just doing a lot of lecturing, you know, so I'm hitting the lecture circuit. You can go to my site and find out those places. A lot of our medical conferences, but there's a lot that I'm going to. That I'll be lecturing at ASPRI. I'm lecturing at this Da Vinci conference, Da Vinci Mastermind. So these are kind of more public conferences. So if you guys go to my site, you can sort of find those things. 'Cause I think there's a lot, like one of my, I think both of our goals is to try and teach medicine and not just, you know, to try and counteract some of the social media that's become so overwhelmed with nonsense. So I think both of us are really trying hard to try and, you know, get a little bit more of a presence there. It's always hard. You're good at it, we're not so good at it.
Yeah, we're gonna make you good at it because that's the point in doing this.
So I am hitting the lecture circuit too, not as much as my friend Betsy, but I'm getting there. I'm like just slow, I'm like low and slow, right? But, um, yeah, I have some conferences coming up next month like IHS and COM, which were so— that's where such a great conference. We love comms.
Yeah.
And then I have a few in April. Is it the Advancement of Medicine? I always forget. It's A-H-M something. It's in April. It's on my website. And then also we have this women's longevity conference that we're speaking at in Turkey in May.
I'll be like, oh, what? There are longevity conferences in Turkey, especially geared to women.
Yeah.
So be really interested in it.
Then I have the AOT coming up, which is in May. So yeah, so I have some like exciting—
or so, um, ourselves and Dr. Kehler are putting together a little— I won't call a podcast, but a few, um, little podcast-like episodes. Yeah, kind of doing exactly this. Yeah, together where we really just chat about topics that, you know, where you can bring a lot of this stuff forward here, different opinions.
Yeah, yeah. And we— and it's like relatable, you know, we're awesome.
We're gonna be filming all 4 episodes of that, and, and we really want you to on as a guest at some point, if you don't mind.
Would you, would you come on?
I would do anything for you guys.
So you're going to come on at one of us called Medical Mavericks? We're called the Medical Mavericks. Do you like that?
I love it.
What do you think of that, John?
Within reason, I would do anything for you guys, especially—
you're sweet.
No, I would. I, I really would. You— I don't— I can't ever really tell you what all you do for me because it's just— there's not words. Oh, But I always want to give the credit where the credit is due and anything of impact.
You know, and you know, Dylan, I've told you this before, is I, you know, there's so much out there now in the social media world and I love that you are trying. I mean, for you guys that don't know, Dylan's taken my course. He's learning, he's learning the science. You know, I love that you're doing that instead of just out there sort of spreading, you know, stuff that—
And with such authenticity.
Thank you.
You are such an authentic person.
I want to know everything.
Yeah, but you're like the best. Thank you so much.
Hey, look, I only know one way to do things. I'm only smart because I hang out with the smartest people in the world. I don't know.
Yeah, I do the same thing.
You have to. Yes, you can. You can never know too much. You always know too little.
Always learning. Perpetual student.
Yes. Yeah, I mean, I always say Michael Jordan didn't stay great by not shooting anymore, practicing every day. I try to learn something every day.
And we always have to be willing to change our mind.
That's right.
Right. That's huge. It's like, you know how we've done things, like, they're like, oh, I That was stupid. You know, I mean, there's so many things that we look back on and we're like, why would I do that?
Fuck, I gotta, I could write a book just on the shit I've done wrong or said.
Right. But that's okay. It's so funny cuz I, I was a competitive swimmer growing up and I swam D1 in college, but my coaches always told me I was really coachable. Yeah. Like, and I feel like I'm co— I feel like I can like basically parlay that into like any part of my life, you know? And cuz I love being coached and I love learning and I love like exploring all these new things and it's okay if I'm, and it's okay if I'm wrong. Right.
I think the best things that we could have internally is accountability and humility.
Yeah.
Because if you have those, you can always accept responsibility for what you've done wrong. And when you do something good, you're humble about it and you just appreciate that people hear it and see what you're trying to say. When you start getting too big for your own shit, that's when things go wrong. That's when you know everything.
That's what happens with a lot of people, unfortunately.
And you You have to.
I mean, there's supplements I was really getting down on, and then I learned, and then, yeah, and they're like, oh, actually the evidence is not really pointing that way, or our results. Yeah, we have the advantage of we see the results in our kitchens, right? And yeah, you know, it looks great on paper, right? It looks so great.
But that's the point. That's okay because you're continually learning and understanding, so you, you know, so you're able to pivot, I think, and do the right thing.
Teachers have made the most mistakes. They just don't make the same ones overnight, right?
You learn from it and then you change and you pivot. Yeah, you know, and that's okay.
You have to be willing to admit and fix and correct and then learn and teach, and that's what we try to do here.
Yeah.
I thank you guys again for coming and seeing me, taking the time and doing this, and I like literally would do this with you every day if I could. I just— I value the shit out of this to the highest extent.
So feeling is mutual.
Yeah, thank you so much.
Appreciate, love, and adore you, and, and we're really happy because we all left hugely cold weather to come to—
I know, it could not have been more perfect timing. Just—
it's an open invite.
The rest of the world— Arizona seems to be protected.
That's why I'm— that's part of the reason I moved.
Weird. It's sort of bizarre.
Yeah, I love it. And, uh, those early morning walks in tank tops in the winter are beautiful, let me tell you.
I'm sure they are.
I will put every single way to follow you guys and contact you in the descriptions. I will reiterate reiterate, Boulder Longevity, Terrain Health, and everything else that they do. Follow them. You will not learn more from more trustworthy and better people, I assure you. So that being said, stay tuned for plenty more to come. Dylan Gemelli, Dr. Elizabeth Yurth, Dr. Robin Rose signing off.
Thank you guys.
Bye. Thanks.
Episode #111 Featuring Dr. Elizabeth Yurth and Dr. Robin Rose! The MOST COMPREHENSIVE Functional Medicine Interview to date!
I have made it frequently known how important Dr. Elizabeth Yurth is to me and her role as a mentor to me. I go to very few people when I need trusted advice and guidance, but she has been and will always be my GO TO person for this. She is also my only 3 time guest on the show. Dr. Robin Rose is one of the most well versed covid experts I have yet to encounter. Getting to know her since we met, she is not only one of the most well rounded functional medicine doctors I have met, but her genuine care and desire to TRULY change lives is on an entirely different level. These two together made for some of my best content to date! Get your minds rested and ready because the information in this interview is not only life changing, but abounding in wisdom and knowledge!
We begin discussing SGLT2 inhibitors and go into deep detail on the mechanism of action and the wide versatility they have on our health especially as it pertains to heart health, diabetes and longevity. We then switch to everyone's favorite topic these days, GLP-1's. This is a detailed conversation with some of the most experienced and well versed people on the planet and there is NO HOLDING BACK. We discuss the PROPER use and why people that have bad reactions are often misusing and misunderstanding them. There is a detailed discussion on the potential long term effects from us as well as potential and likely weight gain once discontinuing use. Rapid weight loss dangers along with the mega importance of hydration is discussed along with its impact on muscle health. We then discuss plasmalogens and their effect on brain health along with environmental problems that damage cognitive function. We cover the high level of damage that covid has shown to have on brain function. There is an extremely detailed discussion on metabolic flexibility, the importance of fats and balancing macronutrients to ensure the most complete and thorough diet is achieved. This is PRICELESS information that goes extremely in depth on all aspects of diet and overcoming the many polarizing discussions that are growing by the day. We take a deep look at the best supplements for mitochondrial health and address overuse of supplements, pinpointing the ones we generally do not need! This is a small fraction of the immense depths this interview goes. This session is like no other and I strongly urge everyone to listen closely to a pair of the most in tuned and brilliant minds on the planet! DO NOT MISS THIS EPISODE!!
Visit the Boulder Longevity Institute:
https://boulderlongevity.com/
Follow Dr. Elizabeth Yurth on instagram:
https://www.instagram.com/dryurth/
Visit Terrain Health:
https://terrainhealth.org/
Follow Dr. Robin Rose on instagram:
https://www.instagram.com/dr.robinrose/
Today's episode is sponsored by Apollo Neuro!
Get the Apollo Neuro for $99 OFF!! USE CODE GEMELLI to save
https://apolloneuro.com/gemelli
________________________________________________________________________________________
Qualia Life Supplements: Save 50% off PLUS AND ADDITIONAL 15% off with my code DYLAN
www.qualialife.com/dylan
The worlds FIRST EVER Topical Glutathione at AURO WELLNESS! SAVE 15% with code "DYLAN"
https://aurowellness.com/dylangemelli
To PURCHASE MITOPURE visit Dylan's landing page and use code DYLAN to save 20% OFF!!
https://shop.timeline.com/DYLAN
Transcend Company: The ULTIMATE Health and Wellness Clinic! USE CODE "DYLAN" to save!
https://transcendcompany.com/?snowball=DYLAN
TONUM supplements for the MIND AND BODY! USE CODE "DYLAN" to save!!
https://www.tonum.com/DYLAN
TRULY Increase Your NAD LEVELS with WONDERFEEL NMN:
https://getwonderfeel.com/?utm_source=DylanGemelli&utm_medium=podcast
MESCREEN: The world's first and only at home mitochondrial efficiency test
Save $100 with CODE DYLAN
https://mescreen.com/cart/47561239626013:1?discount=&ref=DYLAN
HIRE DYLAN ON THE MINNECT APP HERE:
expert.minnect.com/@DylanGemelli
Follow Dylan on Instagram, Facebook, Twitter and Tiktok @dylangemelli and PLEASE SUBSCRIBE and leave reviews!!
MAKE SURE TO GO TO DYLAN'S YOUTUBE CHANNEL for MORE video content!!
https://www.youtube.com/@DylanGemelliBiohacking
Email Dylan for booking, collaborations and/or to apply for the Dylan Gemelli Podcast
DylanGemelli@gmail.com
Visit Dylan's Homepage
https://dylangemelli.com