Transcript of Most Replayed Moment: Your Food Could Be Making You Depressed! How Diet Impacts Mental Health!

We talk a lot about diet and food on this show. As it relates to metabolism and mental health, diet.

Diet is huge. And most people have no clue that diet plays any role in mental illness or mental health. 95% of mental health clinicians think it's laughable that anybody would suggest that diet can play a role in mental illness. They think it's laughable.

What do you think?

I think if you do a deep dive into the science, all of the science that we have accumulated over the last 100 years and longer, sometimes. If you do a deep dive into all of those neuroimaging studies that we we've been doing, all of the genetic studies we've been doing, all of the neurotransmitter and hormone studies and trauma studies and adverse childhood experiences studies. If you do a deep dive into the science and you understand what is happening in the brains and bodies of people as a consequence of those things or what could be causing those things. If you put it all together, you come to this sound I invite that mental disorders are metabolic in nature, and there is no questioning whatsoever. It is incontrovertible that diet plays a massive huge role in metabolism. Therefore, I believe very strongly that diet might be playing a role in the mental health epidemic that we are seeing, and it also might provide an avenue of hope and healing and recovery. I use the word might as the scientist in me, as the clinician in me? I know without certainty. It can heal and recover people who have had chronic, horrible debilitating mental illnesses.

I know from my own personal story, when I was in medical school and residency, I'm still suffering from low grade depression, OCD, other symptoms. But I also developed what's called metabolic syndrome. I developed high blood pressure, high cholesterol, prediabetes, and I wasn't really overweight. I was exercising. I was following a low fat diet, mostly of processed foods because they're cheaper. But that was the diet that was touted as a healthy diet. It was low in fat. And as long as it was low in fat, that was supposed to be good for us. And my metabolic syndrome just kept getting worse and worse. And so at some point, in order to treat my metabolic syndrome, I changed my diet to essentially a low carbohydrate diet. And within Three months, my metabolic syndrome was completely gone. But the thing that just dumbfounded me was that my mental health was better than it had ever been in my entire life. I just couldn't believe what I was experiencing. I didn't know that I could be that a person. I didn't know that I could be happy and positive and energetic and confident. I had no idea. I didn't think that was in me.

And by changing my diet, all of those things happened.

At the level of the mitochondria, are you saying, do you believe that because you changed your diet to more natural, healthier foods, at the level of the mitochondria, the mitochondria were able to function more naturally themselves in a more functional way, which meant that the chemicals they released and the processes they go through were more consistent with positive mental health. Is that the simpleton's way of understanding it? And before then, you talked about manmade compounds in the foods, et cetera. I'm assuming you were saying that some of the modern foods that we eat, the ultra-processed foods that have all of these random named chemicals inside them that we see on the labels, the mitochondria don't how to deal with that. So it's causing the same dysregulation and dysfunction that they might see if we'd gone through an extreme trauma or something else or some other adverse environmental situation. It's just this dysfunction of the mitochondria, which is causing the knock-on effects we see. But there's many things that can cause dysfunction in the mitochondria. We went through a bunch of them earlier. Is that a simple way of understanding it?

A hundred %.

Okay, great.

It's perfect.

Super interesting. Okay, so on that point, then, we have to zoom in on this thing of diet. If you wanted my mitochondria to be perfect, and maybe even give me a case study of patients you've worked with that you've prescribed a certain diet to, what diet, what food would you tell me to eat? And what would you tell me not to eat?

I actually don't have a one-size-fits-all prescription. I want to say that upfront. I would want to know who am I working with and how is their mental and metabolic health now?

Me.

So you. So I would want more details. Are you having symptoms of any mental health condition?

I would say no. However, I can have moments where I feel a little bit anxious. So I've been through a lot of, I'd say, stressful events in my life because I was running a big business. We had hundreds of employees, pay days all the time. So I had At one point, I had this constant, subtle stress.

I would want to know, do you feel like you have anxiety for no good reason?

Sometimes. Sometimes it can feel a little bit like that. It's very infrequent, I'd say. But I can also have moments where I just think of something and then I get the same... It's almost like the fight or flight response has just kicked in.

But you think of something adverse or stressful? Yeah. The one thing I would say about that, and we could get into a lot more details, which we probably don't want to do now.

I don't mind.

Podcast. But my strong guess, based on just what you've said, is that that level of stress and anxiety is, quote, unquote, normal.

Okay.

Because you are sensing, I have to go do something that's really scary right now, or I have to go do something that's going to ruin someone's life or that might threaten my success. It is normal and actually healthy to have anxiety and stress in those situations. The anxiety and stress can sometimes be quite helpful and adaptive because it can make you pause and reflect on, Is this really what I want to do? As opposed as opposed to being overly confident and just proceeding. Your own personal history almost certainly informs your level of stress response. Again, so if you go back to your own traumas, you're going to remember when I'm facing a situation like this, it's helpful to be on hyper alert. It's helpful to be hyper vigilant. Your body and brain will remember that helped you navigate this safely and effectively.

But if I have that profile, if I have that mental health profile now as I sit here, and then for the next decade, I ate processed junk food, am I going to send my mitochondria into disarray, which is going to increase the probability that I have a mental health disorder?

Yes. I think yes. There's no way we will ever be able to do a human-randomized controlled trial to test that precise-Unethical, right? Hypothesis. Unethical, right? But we have large epidemiological studies that strongly suggests that people who eat a lot of ultra-process food have higher risk for developing depression, anxiety, and other mental disorders. Based on the science, the granular science, based on animal models. So we can do that to mice and rats. And in fact, that's exactly what we see in mice and rats. We feed them an obesogenic diet, which is usually high in fat, high in carbohydrates, ultra-processed foods. Some researchers have fed rats and mice cafeteria diets, where they feed them a lot of delicious junk food. And those mice develop higher rates of obesity, but also higher rates of diabetes and prediabetes. And oh, by the way, also higher rates of depression and anxiety, because those are the two things that we can measure in mice and rats. We can't necessarily measure ADHD symptoms. It's really hard to actually measure psychotic symptoms, but we can measure depression and anxiety symptoms pretty well in animals. And so in animal models, we know that that's unequivocally true.

We see the same in humans, though, because I was reading your book and in chapter four, you say people with ADHD are more likely to develop obesity. People who are obese are 50% more likely to develop bipolar and 25% more likely to develop anxiety or depression. And weight gain around the time of puberty leads to a 400% increase in the chance of depression by the age of 24.

Yes. And insulin resistance at age nine increases your chances of developing a psychotic at-risk mental state, which is meaning you're at high risk for developing schizophrenia or bipolar disorder, 500 %.

And Alzheimer's?

All mental disorders are associated with an increased risk of Alzheimer's disease. Anywhere from the lowest is 50 % increased risk, and the highest is 2,000 % increased risk.

And the thread that you despite all of these problems is metabolism.

Metabolism. At the end of the day, you have to talk about mitochondria in order to understand metabolism. Only 7% of US citizens have no signs of metabolic health problems, meaning 93% or so of US residents will have at least one of the biomarkers of metabolic syndrome, meaning they have prediabetes or abnormal lipids or high blood pressure or abdominal obesity or abdominal fat, excessive abdominal fat.

So what do we offer those 93 %?

Those people diet interventions would absolutely be a part of a healing strategy. A part of it, not the only strategy. I would want to know about their sleep. I would want to know about substance use. I would want to know about medications, lots of things. But for dietary interventions, I would want to meet them where they're at and just find out, where are you at? What are you eating? Do you have preferences or demands for what your diet should be?

Could you give me a case study then? Maybe a more extreme case study from your practice that you've seen.

I can give you the simple cases which probably apply to the majority of human beings on the planet. But if it's okay, I'd rather give you the extreme case. Because a lot of people are skeptical. They probably hear me saying this and they think, well, you're just talking about general health and wellness. What about people with real mental illness? What about people like your mother, whose lives were decimated by mental illness? This doesn't have anything to do with them. And what I'm here to say is, no, actually, this has everything to do with them, too. But yes, it applies to just common everyday people. But probably, so one story that I will just share, because it's probably one of the most powerful stories I know. It was a woman whose real name was Doris. In the book, I called her Mildred because I changed everybody's names. But she actually gave me permission to use her real name. In honor of her, I want to use her real name. She was a woman who actually had a horrible abuse of childhood, lots of trauma. By the time she turned 17, she started having daily hallucinations delusions, and was diagnosed with schizophrenia.

Over the ensuing decades, she tried numerous antipsychotic mood stabilizers, antidepressants, and other medicines, but none of them stopped her symptoms. She remained with all of the symptoms of schizophrenia. She ended up gaining a massive amount of weight. She ended up weighing about 330 pounds by the time she was 70. Her life was devastated by this diagnosis. She had a court-appointed guardian to manage her financial affairs and other affairs. She had professionals coming into her home to help her with paying bills and grocery shopping and stuff like that because she couldn't do it for herself, which is not at all unusual for people with schizophrenia. Between the ages of 68 and 70, she tried to kill herself at least six times and was hospitalized for those suicide attempts. She hated herself and she hated her life. When she was 70 years old, her doctor told her, You're overweight and you need to go lose some weight. She was referred to a weight loss clinic at Duke University, where they just so happened to be using the ketogenic diet as a dietary, as a weight loss tool. For whatever reason, she decided to give it a try.

She tries the ketogenic diet. Within two weeks, not only does she start losing weight, but she notices dramatic reduction in her hallucinations and delusions. Within months, all of her symptoms of schizophrenia were in full and complete remission. She starts tapering off her psychiatric meds. Within about six months, she was off all of her psychiatric meds, and her symptoms of schizophrenia remained in remission. Doris went on to live for another 15 years, symptom-free, Medication free, out of psychiatric hospitals, no more suicide attempts. She stopped seeing mental health professionals pretty quickly because they were worthless in her mind. They hadn't really helped all that much. She lost 150 pounds and kept it off until the day she died. She ended up dying at the age of 85 of COVID pneumonia. But her story tells us, like we could get if you want, we don't have to, we could get into the science of the ketogenic diet and what it's doing to metabolism and mitochondria. I'd love But there's an entire story that helps us understand what happened to her and how exactly that resulted in her really spectacular and almost miraculous recovery. So unbeknownst to most people, most people know the ketogenic diet is a fad diet, and a lot of people are really worried about it.

They've heard that it's dangerous. It'll give you a heart attack. You'll die. Unbeknownst to most people, the ketogenic diet was developed over 100 years ago now by a physician for one and only one purpose. It was developed to stop seizures. And in fact, the ketogenic diet has been studied extensively for its effects on the brain over the past 100 years. And it is an evidence-based treatment for epilepsy. And the reason that is so important is because We use epilepsy treatments in psychiatry all the time. Lots of the medications that we prescribe to psychiatric patients are, in fact, epilepsy treatments. We know that there's a lot of overlap between epilepsy and mental illness, and that treatments that help with epilepsy can also help with mental illness. And so we actually know more about the biology of the ketogenic diet and its effects on the brain than we do any other dietary intervention. It changes neurotransmitter systems. It decreases brain inflammation. It changes the gut microbiome in beneficial ways. It actually changes gene expression or epigenetics. But most important and relevant to my theory is it improves mitochondria and mitochondrial function. And if you do it long enough, over a long enough period of time, you can actually repair repair mitochondrial dysfunction in cells, at least for some people.

And then you can actually stop the diet. So in the epilepsy world, when neurologists use this diet to stop seizures, it's usually not a lifetime treatment. They usually only need to do the diet for anywhere from 2-5 years. Many people, about a third of people who have treatment-resistant seizures will become seizure-free. And another third, so two-thirds total, another third will have a dramatic reduction in seizure frequency. So that leaves a third for whom it's not really working. But these are people with treatment-resistant epilepsy, and there's no treatment that's going to work for everybody because we need to look at all the other things involved. If, say, somebody has seizure cessation, they get rid of their seizures on a ketogenic diet, usually they have to do it for 2-5 years, somewhere in there, and Their clinician will help them decide how long they should do it. And then they can stop the diet. Most often, the seizures don't come back. It seems to actually heal the brain.

What is that diet adding or subtracting from the body that's causing that pretty phenomenal effect? Do people know?

The real answer is we don't entirely understand. We don't know.

The ketogenic diet removes sugar, for example.

It does.

Pretty much entirely. I mean, I've been on that diet for about... I was on the diet for about eight weeks or so just to try, and I couldn't have anything with sugar in it, pretty much.

No sugar, no carbohydrates, very few carbohydrates. So some people will argue, well, the diet is getting rid of gluten, and gluten is maybe the toxic thing. Other people will argue, oh, the diet is adding some extra protein or meat, and maybe that's replacing a nutrient deficiency like vitamin B12 deficiency or something like that, or iron deficiency. And all of those things might be true for some people. I don't think those are the primary explanation. I mean, obviously, if somebody has vitamin B12 deficiency, replacing vitamin B12 is essential. If somebody has iron deficiency, yes, recognizing that and replacing it. But most people don't have those deficiencies, and they can still have mental symptoms or mental health problems. I believe what the diet is doing is it forces a transition in brain and body metabolism, essentially. And that transition is actually mediated through mitochondria. So the ketogenic diet forces your liver to start producing ketone bodies. So it forces your liver to break down fat. So you're losing fat from your fat stores, but that fat is being shuttled to the liver. And then the liver takes that fat and breaks it down. I shouldn't say all of the fat is being shuttled to the liver.

Some of the fat is going to muscles and other tissues and just being used directly. But a fair amount of the fat is actually being shuttled to the liver. And then that fat is being converted into ketone bodies. Some of it is being converted into glucose so that you maintain normal glucose levels through this. Those ketone bodies are then going up to the brain and fueling brain cells. But those ketone bodies are actually doing so much more. They're changing mitochondrial function. They're changing epigenetics, they're changing neurotransmitters and inflammation and all sorts of things. But at the end of the day, I'm convinced that it's really the metabolic changes and the mitochondrial changes that are so important and that are so instrumental in these dramatic improvements and things like stopping seizures or stopping hallucinations and delusions.

What about fasting? There's been a lot of talk, especially recently, about fasting and the impact that that can have in our mental health. Do you think fasting is a positive for our mental health?

It depends on the person. The ketogenic diet actually mimics the fasting state. That's why it was produced. The ketogenic diet was actually developed by a physician recognizing that fasting can have really powerful brain effects, including stopping seizures. If you're out on an island and your friend starts seizing uncontrollably, the best thing to do is to fast them. Even if the seizures stop intermittently, you would think, Oh, let's feed you to keep up your sustenance and take care of you. The best thing to do for your friend, if they are seizing repetitive over days or months, the best thing to do is to fast your friend and to tell them, Let's have you go without food for a few days. And that can stop the seizures. The challenge with fasting is that you could starve to death if you do it long enough. That's not a very good treatment for your friend on the island. And this physician who developed the ketogenic diet recognize that. And so that's why he developed the ketogenic diet was really looking to see, can we mimic the fasting state with a diet and get these longer term benefits Back to your question, can fasting play a role?

100%, yes, fasting can play a role. And fasting is doing pretty much the same thing that the ketogenic diet is doing. It's changing mitochondrial biology. It's improving mitochondrial function, changing neurotransmitters, changing the gut microbiome, improving insulin signaling and insulin resistance. It's doing all sorts of beneficial things. There are a couple of caveats with fasting, though. One is that people who are underweight should not fast. So that includes people with eating disorders who are emaciated or underweight. But it also includes people who have had severe depression and lost weight as a result of their severe depression or people with cancer who have lost a significant amount of weight. Fasting is not good for them. Fasting mimicking diets, like ketogenic diets may in fact be very powerful for those people. But it needs to be done in a safe, supervised medical way.

Sugar. What impact does that have on the mitochondria? If I've got a super high sugar diet, is that impacting my mitochondria in some way and therefore my metabolism?

It is. So low intake of sugar in people who are otherwise healthy is perfectly fine and acceptable. So lots of people can consume treats every now and then or desserts a few times a week or special holiday. They can maybe even binge on sugar over the holidays, and they don't have any problems as a result of it. And that is fine. If that's the way it's working out, again, only 7% of the population is metabolically healthy. Healthy. The majority of people, that's not the way it's working out. Again, only 7% of the population is metabolically healthy. So the majority of people, that's not the way it's working out. So high levels of sugar over time, we know, can impair mitochondrial function. There's this term called oxidative stress. And oxidative stress is primarily, it's directly related to mitochondria because mitochondria are producing the energy, and then that energy production results in oxidative stress. And oxidative stress, we've known for decades, is bad for cells, and it is highly correlated with all of the metabolic disorders and all of the mental disorders, high levels of oxidative stress in different cells, in different people with different diagnosis, high levels of oxidative stress are a unifying theme.

But that is a reflection of mitochondrial dysfunction. So we know that if you eat a lot of sugar over time, it can dysregulate glucose levels, and then those high glucose levels can cause mitochondrial dysfunction, and you can end up on the downward spiral.

What you just listened to was a most replayed moment from a previous episode. If you want to listen to that full episode, I've linked it down below. Check the description. Thank you.